Aes 14797

From TFCatWiki

Jump to: navigation, search

External Links

Gene ID: 14797
Gene symbol: aes
Gene Description: amino-terminal enhancer of split
Aliases: AL024115; Grg; Grg5
Human Ortholog Gene ID: [166]
Reviewer Judgement: TF Gene
Functional Classification: Transcription Factor Binding: tf co-factor binding
Homolog Cluster(s): 107986

Evidence:

Pubmed ID Function Species Evidence Strength Reviewer's Comments Reviewer
[10660609] TF PPI Human Strong Using the yeast two-hybrid system, an in vitro GST pull down assay and by in vivo co-immunoprecipitation study in 293 cells, AES is shown to interact with the p65 subunit of the transcription factor NF-kappa B. Transient transfection assays show AES represses gene expression induced by several regulatory molecules including p65. Amy Ticoll
[11416139] TF PPI Human Strong AR is shown to interact specifically with AES in yeast two-hybrid, mammalian two-hybrid in 293T cells, and coimmunoprecipitation experiments. AES represses AR-dependent luciferase gene expression induced by AR in HeLa cells. In protein-protein pull-down assays, basal transcription factor TFIIE is specifically retained by GST-AES. Experiments conducted with appropriate controls. Amy Ticoll
Additional Reviewer Comments:
Reviewer: Amy Ticoll

AES is shown to interact with other transcription factors using two-hybrid, coimmunoprecipitation, and pull-down assays. Transfection assays show that AES represses gene expression induced by several regulatory molecules.


DISCUSSION PAGE link for this gene

VIEW gene annotation feedback in the [TFCat Annotation Feedback Reports Inquiry]

REPORT gene annotation feedback on the [TFCat Annotation Feedback Reporting System] Help is available here


The section below defines information for semantic searching. Please see the help page for more information on this section.

Facts about Aes 14797RDF feed
Gene description amino-terminal enhancer of split  +
Gene id 14,797  +
Gene judgment TF Gene  +
Gene symbol aes  +, AL024115  +, Grg  +, and Grg5  +
Gene taxonomy Transcription Factor Binding: tf co-factor binding  +
Homolog cluster 107,986  +
Personal tools