Aes 14797

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Gene ID: 14797
Gene symbol: aes
Gene Description: amino-terminal enhancer of split
Aliases: AL024115; Grg; Grg5
Human Ortholog Gene ID: [166]
Reviewer Judgement: TF Gene
Functional Classification: Transcription Factor Binding: tf co-factor binding
Homolog Cluster(s): 107986


Pubmed ID Function Species Evidence Strength Reviewer's Comments Reviewer
[10660609] TF PPI Human Strong Using the yeast two-hybrid system, an in vitro GST pull down assay and by in vivo co-immunoprecipitation study in 293 cells, AES is shown to interact with the p65 subunit of the transcription factor NF-kappa B. Transient transfection assays show AES represses gene expression induced by several regulatory molecules including p65. Amy Ticoll
[11416139] TF PPI Human Strong AR is shown to interact specifically with AES in yeast two-hybrid, mammalian two-hybrid in 293T cells, and coimmunoprecipitation experiments. AES represses AR-dependent luciferase gene expression induced by AR in HeLa cells. In protein-protein pull-down assays, basal transcription factor TFIIE is specifically retained by GST-AES. Experiments conducted with appropriate controls. Amy Ticoll
Additional Reviewer Comments:
Reviewer: Amy Ticoll

AES is shown to interact with other transcription factors using two-hybrid, coimmunoprecipitation, and pull-down assays. Transfection assays show that AES represses gene expression induced by several regulatory molecules.

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Facts about Aes 14797RDF feed
Gene description amino-terminal enhancer of split  +
Gene id 14,797  +
Gene judgment TF Gene  +
Gene symbol aes  +, AL024115  +, Grg  +, and Grg5  +
Gene taxonomy Transcription Factor Binding: tf co-factor binding  +
Homolog cluster 107,986  +
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