Apex1 11792

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Gene ID: 11792
Gene symbol: apex1
Gene Description: apurinic/apyrimidinic endonuclease 1
Aliases: APE; Apex; HAP1; Ref-1
Human Ortholog Gene ID: [328]
Reviewer Judgement: TF Gene Candidate
Functional Classification: Transcription Factor Binding: tf co-factor binding
Homolog Cluster(s): 11792

Evidence:

Pubmed ID Function Species Evidence Strength Reviewer's Comments Reviewer
[1380454] Other Human Strong EMSA shows that recombinant human Ref1 induces the binding of recombinant Jun protein or Jun extracted from HeLa nuclei to AP-1 DNA elements. This binding is decreased upon immunodepletion of either recombinant Ref1 or HeLa nuclear extracts with anti-Ref1 antibody. Magdalena Swanson
[15084519] TF PPI Rat Strong Coimmunoprecipitation studies of nuclear extracts from rat pulmonary artery endothelial cells (PAECs) with anti-Ref-1 antibody precipitated p300, CREB, and AFT proteins . Magdalena Swanson
[15674341] Other Human Medium SDS-PAGE and Western blot analysis shows that recombinant human Ref-1 promotes recombinant human p53 tetramer formation in vitro. Magdalena Swanson
Additional Reviewer Comments:
Reviewer: Magdalena Swanson

Apex1 is a TF candidate. It interacts with transcription factors in coimmunoprecipitation studies. It also aids Jun in binding AP-1 DNA elements in EMSA studies, although Apex1 does not bind these elements itself. SDS-PAGE and Western blot analysis shows that recombinant human Ref-1 promotes recombinant human p53 tetramer formation in vitro. There is no evidence that Apex1 activates transcription directly.


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Facts about Apex1 11792RDF feed
Gene description apurinic/apyrimidinic endonuclease 1  +
Gene id 11,792  +
Gene judgment TF Gene Candidate  +
Gene symbol apex1  +, APE  +, Apex  +, HAP1  +, and Ref-1  +
Gene taxonomy Transcription Factor Binding: tf co-factor binding  +
Homolog cluster 11,792  +
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