Arid1b 239985

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Gene ID: 239985
Gene symbol: arid1b
Gene Description: at rich interactive domain 1b (swi1 like)
Aliases: 8030481M12; 9330189K18Rik; AI836955; Ardi1b; B230217J03Rik; mKIAA1235
Human Ortholog Gene ID: [57492]
Reviewer Judgement: TF Gene
Functional Classification: Transcription Regulatory Activity: heterochromatin interaction/binding;

DNA-Binding: non-sequence-specific; Transcription Factor Binding: tf co-factor binding

DBD Protein Group Classification: Helix-Turn-Helix Group
DBD Protein Group/Family Classification: Helix-Turn-Helix Group / Arid Domain Family
Homolog Cluster(s): 239985

Evidence:

Pubmed ID Function Species Evidence Strength Reviewer's Comments Reviewer
[12200431] TF PPI Human Strong Mass spectrometric analysis and immunoblotting from HeLa nuclear extracts demonstrate the presence of hOsa2 (ARID1B) in SWI/SNF-A. Co-precipitation studies from C33A cells indicate that hOsa2 associates with BRG1 and hBRM (essential ATPase subunits of SWI/SNF- related complexes) through the C-terminal domain of hOsa. In cultured mammalian T47D cells, hOsa2 stimulates transcription mediated by the steroid hormone receptors. Amy Ticoll
[15170388] Non-specific DNA; TF PPI Human Medium Immunocomplex analysis in Saos-2 cells provides direct evidence that endogenous ARID1B is associated with SWI/SNF-related complexes. Additional immunocomplex analysis indicates that ARID1B associates with both ATPases (BRG1 and hBRM) of the complex in vivo. Analysis of DNA-binding behaviour in a in a DNA pull-down assay indicates that ARID1B binds DNA in a non-sequence-specific manner. Amy Ticoll
Additional Reviewer Comments:
Reviewer: Amy Ticoll

The mammalian SWI/SNF-related complexes facilitate gene transcription by remodeling chromatin using the energy of ATP hydrolysis, and may interact with site-specific transcription factors or other cofactors. Mass spectrometric analysis and immunoblotting demonstrate the presence of ARID1B in SWI/SNF-related complexes. Co-precipitation studies indicate that ARID1B associates with BRG1 and hBRM, essential ATPase subunits of SWI/SNF-related complexes. Analysis of DNA-binding behaviour in a in a DNA pull-down assay indicates that ARID1B binds DNA in a non-sequence-specific manner. ARID1B stimulates transcription mediated by the steroid hormone receptors.


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Facts about Arid1b 239985RDF feed
Gene description at rich interactive domain 1b (swi1 like)  +
Gene id 239,985  +
Gene judgment TF Gene  +
Gene symbol arid1b  +, 8030481M12  +, 9330189K18Rik  +, AI836955  +, Ardi1b  +, B230217J03Rik  +, and mKIAA1235  +
Gene taxonomy Transcription Regulatory Activity: heterochromatin interaction/binding  +, DNA-Binding: non-sequence-specific  +, and Transcription Factor Binding: tf co-factor binding  +
Homolog cluster 239,985  +
Protein family 1.1 Helix-Turn-Helix Group/109 Arid Domain Family  +
Protein group 1.1 Helix-Turn-Helix Group   +
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