Arid2 77044

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Gene ID: 77044
Gene symbol: arid2
Gene Description: at rich interactive domain 2 (arid-rfx like)
Aliases: 4432409D24Rik; zipzap/p200
Human Ortholog Gene ID: [196528]
Reviewer Judgement: TF Gene
Functional Classification: Transcription Factor Binding: tf co-factor binding
Homolog Cluster(s): 77044

Evidence:

Pubmed ID Function Species Evidence Strength Reviewer's Comments Reviewer
[16782067] Co-activation Human; Mouse Medium SRF and zipzap/p200 (Arid2) co-immunoprecipitate in NIH3T3 cells, suggesting the two proteins interact in vivo. A mammalian two-hybrid system suggests SRF has a weak interaction with zipzap protein. In a co-immunoprecipitation assay to test whether zipzap/p200 protein binds to SRF in the presence of other SRF cofactor(s), zipzap/p200 was found in a protein complex with SRF and other SRF-binding proteins (including p49/STRAP and Nkx2.5) . Zipzap/p200 with SRF activated the promoter activity of cardiac actin, MLC2v, and ANF genes. Zipzap/p200 co-transfected with another SRF cofactor, myocardin, results in synergistic activation of the ANF promoter. Amy Ticoll
Additional Reviewer Comments:
Reviewer: Amy Ticoll

The zipzap/p200 (Arid2) protein has two classic C2H2 zinc fingers. Zipzap/p200 co-immunoprecipitates with SRF and SRF cofactors, however a mammalian two-hybrid system suggests only a weak interaction between SRF and zipzap. Zipzap/p200 with SRF activated the promoter activity of cardiac actin, MLC2v, and ANF genes. Zipzap/p200 co-transfected with another SRF cofactor, myocardin, results in synergistic activation of the ANF promoter.


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Facts about Arid2 77044RDF feed
Gene description at rich interactive domain 2 (arid-rfx like)  +
Gene id 77,044  +
Gene judgment TF Gene  +
Gene symbol arid2  +, 4432409D24Rik  +, and zipzap/p200  +
Gene taxonomy Transcription Factor Binding: tf co-factor binding  +
Homolog cluster 77,044  +
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