Arid3a 13496

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Gene ID: 13496
Gene symbol: arid3a
Gene Description: at rich interactive domain 3a (bright like)
Aliases: Bright; Dri1
Human Ortholog Gene ID: [1820]
Reviewer Judgement: TF Gene
Functional Classification: DNA-Binding: sequence-specific
DBD Protein Group Classification: Helix-Turn-Helix Group
DBD Protein Group/Family Classification: Helix-Turn-Helix Group / Arid Domain Family
Homolog Cluster(s): 13496

Evidence:

Pubmed ID Function Species Evidence Strength Reviewer's Comments Reviewer
[15456761] DNA Binding; Transactivation Mouse Strong EMSA analyses using the prototypic Bright binding site (from the murine S107 V1 promoter region) showed that recombinant murine Bright has DNA binding activity. Real time PCR assays performed using mRNA isolated from CHO cells transduced with murine recombinant Bright, and a reporter gene containing part of the murine V1 S107 family heavy chain gene and promoter sequence with Bright binding sites showed that Bright has transactivaton activity. Magdalena Swanson
Additional Reviewer Comments:
Reviewer: Magdalena Swanson

Arid3a is a TF. The recombinant protein binds DNA that contains Arid3a elements in EMSA studies. Recombinant Arid3a also transactivates a V1 S107 immunoglobulin family heavy chain reporter construct in cotransfection experiments, as evidenced by real time PCR analysis.


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Facts about Arid3a 13496RDF feed
Gene description at rich interactive domain 3a (bright like)  +
Gene id 13,496  +
Gene judgment TF Gene  +
Gene symbol arid3a  +, Bright  +, and Dri1  +
Gene taxonomy DNA-Binding: sequence-specific  +
Homolog cluster 13,496  +
Protein family 1.1 Helix-Turn-Helix Group/109 Arid Domain Family  +
Protein group 1.1 Helix-Turn-Helix Group   +
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