Arid3c 550619

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Gene ID: 550619
Gene symbol: arid3c
Gene Description: at rich interactive domain 3c (bright-like)
Aliases: OTTMUSG00000006683
Human Ortholog Gene ID:
Reviewer Judgement: Indeterminate - There is no evidence for or against this gene's role as a TF
Functional Classification:
Homolog Cluster(s): 13496

Evidence:

Pubmed ID Function Species Evidence Strength Reviewer's Comments Reviewer
[15922553] Other Unknown Unknown Arid3C is a member of the ARID (AT-rich interaction domain) protein family, which was named for its DNA binding domain: the AT-rich interactive domain (ARID). The ARID domain contacts both the major and minor grooves binds to bind DNA in a sequence-specific manner. In spite of the family name, not all response elements bound by ARID proteins are AT-rich.

The properties of Arid3c have been inferred on the basis of its homology to other family members and have not been confirmed by experimental evidence.

Rob Sladek
Additional Reviewer Comments:
Reviewer: Rob Sladek

Arid3C is a member of the ARID (AT-rich interaction domain) protein family, which was named for its DNA binding domain: the AT-rich interactive domain (ARID). The ARID domain contacts both the major and minor grooves binds to bind DNA in a sequence-specific manner. In spite of the family name, not all response elements bound by ARID proteins are AT-rich. The properties of Arid3c have been inferred on the basis of its homology to other family members and have not been confirmed by experimental evidence. The REKLESbeta domain is required for Arid3a self-assocaiton and DNA binding (PMID 17400556), but Arid3c has not been shown to bind DNA.


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Facts about Arid3c 550619RDF feed
Gene description at rich interactive domain 3c (bright-like)  +
Gene id 550,619  +
Gene judgment Indeterminate - There is no evidence for or against this gene's role as a TF  +
Gene symbol arid3c  +, and OTTMUSG00000006683  +
Homolog cluster 13,496  +
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