Arnt2 11864

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Gene ID: 11864
Gene symbol: arnt2
Gene Description: aryl hydrocarbon receptor nuclear translocator 2
Aliases: Hif-2b; mKIAA0307
Human Ortholog Gene ID: [9915]
Reviewer Judgement: TF Gene
Functional Classification: DNA-Binding: sequence-specific
DBD Protein Group Classification: Zipper-Type Group
DBD Protein Group/Family Classification: Zipper-Type Group / Helix-Loop-Helix Family
Homolog Cluster(s): 11622; 15206


Pubmed ID Function Species Evidence Strength Reviewer's Comments Reviewer
[8657146] DNA Binding; Transactivation Mouse Strong Performed Gel-shift assays on ARNT2 with a labelled XRE and showed DNA-binding activity. Also showed transactivation using a yeast two-hybrid assay by fusing deletion constructs to the GAL4-DNA binding domain and mapped the activation domain to the C-terminus. Sarav Sundararajan
Additional Reviewer Comments:
Reviewer: Sarav Sundararajan

This gene encodes a sequence-specific transcription factor. Gel shift experiments demonstrated that ARNT2 bound specifically the xenobiotic responsive element (XRE) sequence, while a yeast two-hybrid assay demonstrated transactivation activity.

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Facts about Arnt2 11864RDF feed
Gene description aryl hydrocarbon receptor nuclear translocator 2  +
Gene id 11,864  +
Gene judgment TF Gene  +
Gene symbol arnt2  +, Hif-2b  +, and mKIAA0307  +
Gene taxonomy DNA-Binding: sequence-specific  +
Homolog cluster 11,622  +, and 15,206  +
Protein family 3 Zipper-Type Group/22 Helix-Loop-Helix Family  +
Protein group 3 Zipper-Type Group   +
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