Arx 11878

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Gene ID: 11878
Gene symbol: arx
Gene Description: aristaless related homeobox gene (drosophila)
Aliases:
Human Ortholog Gene ID: [170302]
Reviewer Judgement: TF Gene
Functional Classification: DNA-Binding: sequence-specific
DBD Protein Group Classification: Helix-Turn-Helix Group
DBD Protein Group/Family Classification: Helix-Turn-Helix Group / Homeodomain Family
Homolog Cluster(s): 103889

Evidence:

Pubmed ID Function Species Evidence Strength Reviewer's Comments Reviewer
[15930104] DNA Binding; Transactivation Mouse Medium Strong evidence that Arx binds to a specific site in Pax4 promoter in south-western, EMSA and chIP experiments.

Weak evidence that Arx might repress Pax4 activity. Arx repress basal reporter activity in gene reporter assay using luciferase reporter constructs containing five copies of its binding site.

Elodie Portales-Casamar
Additional Reviewer Comments:
Reviewer: Elodie Portales-Casamar

Strong evidence of DNA specific binding through south-western, EMSA and chIP experiments but poor evidence of transactivation. Only one relevant paper was found.


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Facts about Arx 11878RDF feed
Gene description aristaless related homeobox gene (drosophila)  +
Gene id 11,878  +
Gene judgment TF Gene  +
Gene symbol arx  +
Gene taxonomy DNA-Binding: sequence-specific  +
Homolog cluster 103,889  +
Protein family 1.1 Helix-Turn-Helix Group/2 Homeodomain Family  +
Protein group 1.1 Helix-Turn-Helix Group   +
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