Atf3 11910

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Gene ID: 11910
Gene symbol: atf3
Gene Description: activating transcription factor 3
Aliases: LRG-21
Human Ortholog Gene ID: [467]
Reviewer Judgement: TF Gene
Functional Classification: DNA-Binding: sequence-specific
DBD Protein Group Classification: Zipper-Type Group
DBD Protein Group/Family Classification: Zipper-Type Group / Leucine Zipper Family
Homolog Cluster(s): 107503


Pubmed ID Function Species Evidence Strength Reviewer's Comments Reviewer
[11916968] DNA Binding; Transactivation Human; Mouse Strong Gel shift assay shows binding to the ATF/CRE consensus sequence of the PEPCK promoter. Transient transfection of ATF3 represses activity in a CAT reporter construct driven by the PEPCK promoter. Sarav Sundararajan
[12815047] DNA Binding; Transactivation Mouse Strong Gel-shift assays indicate that ATF3 binds to the CRE/ATF site derived from the mouse proglucagon gene promoter. Also induces expression from a luciferase reporter for the mouse proglucagon gene. Sarav Sundararajan
Additional Reviewer Comments:
Reviewer: Sarav Sundararajan

Conflicting evidence of whether this TF is an activator or a repressor, though most reports indicate that it functions as a repressor.

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Facts about Atf3 11910RDF feed
Gene description activating transcription factor 3  +
Gene id 11,910  +
Gene judgment TF Gene  +
Gene symbol atf3  +, and LRG-21  +
Gene taxonomy DNA-Binding: sequence-specific  +
Homolog cluster 107,503  +
Protein family 3 Zipper-Type Group/21 Leucine Zipper Family  +
Protein group 3 Zipper-Type Group   +
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