Atf4 11911

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Gene ID: 11911
Gene symbol: atf4
Gene Description: activating transcription factor 4
Aliases: Atf-4; C/ATF; CREB2; MGC96460; TAXREB67
Human Ortholog Gene ID: [468]
Reviewer Judgement: TF Gene
Functional Classification: DNA-Binding: sequence-specific
DBD Protein Group Classification: Zipper-Type Group
DBD Protein Group/Family Classification: Zipper-Type Group / Leucine Zipper Family
Homolog Cluster(s): 107503

Evidence:

Pubmed ID Function Species Evidence Strength Reviewer's Comments Reviewer
[15109498] Transactivation Mouse Medium Decrease in Osteocalcin expression observed in Atf4-deficient mice using Alcian blue/alizarin red staining over developmental stages. DNA cotransfection experiments demontrate that an Atf4 expression vector increases activity of an Osteocalcin promoter-luciferase chimeric gene. Debra Fulton
[16000305] Transactivation Mouse Strong ATF4 stimulates the promoter-luciferase reporter gene (contains a single ATF4-binding site (OSE1) and two Runx2-binding sites (OSE2) see PMID: 7891679 ) activity in MC-4 cells. Transfection of C3H10T1/2 cells with expression plasmids and a promoter-luciferase reporter gene demonstrate that ATF4 increases the osteocalcin message level when Runx2 protein is co-expressed. Debra Fulton
Additional Reviewer Comments:
Reviewer: Debra Fulton

DNA cotransfection experiments demontrate that an Atf4 expression vector increases activity of an Osteocalcin promoter-luciferase chimeric gene. ATF4 increases the mouse osteocalcin message level when Runx2 protein is co-expressed.


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Facts about Atf4 11911RDF feed
Gene description activating transcription factor 4  +
Gene id 11,911  +
Gene judgment TF Gene  +
Gene symbol atf4  +, Atf-4  +, C/ATF  +, CREB2  +, MGC96460  +, and TAXREB67  +
Gene taxonomy DNA-Binding: sequence-specific  +
Homolog cluster 107,503  +
Protein family 3 Zipper-Type Group/21 Leucine Zipper Family  +
Protein group 3 Zipper-Type Group   +
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