Atf7 223922

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Gene ID: 223922
Gene symbol: atf7
Gene Description: activating transcription factor 7
Aliases: 1110012F10Rik; 9430065F09Rik; AI549878; C130020M04Rik; MGC31554
Human Ortholog Gene ID: [11016]
Reviewer Judgement: TF Gene
Functional Classification: DNA-Binding: sequence-specific
DBD Protein Group Classification: Zipper-Type Group
DBD Protein Group/Family Classification: Zipper-Type Group / Leucine Zipper Family
Homolog Cluster(s): 107503

Evidence:

Pubmed ID Function Species Evidence Strength Reviewer's Comments Reviewer
[11278933] DNA Binding Mouse Strong EMSA assays show that ATF-7 can bind to CRE elements. Co-immunoprecipitation experiments show that ATF-7 also binds to PRL-1 and that this interaction allows PRL-1 to dephosphorylate ATF-7 Sarav Sundararajan
[15735663] Transactivation Human Strong Reporter assays show that the GAL4(DBD)-ATF-7 fusion can transactivate the UAS-luciferase construct and that this transactivation is mediated through interactions between ATF-7 and hsTAF12. Sarav Sundararajan
[1694576] DNA Binding Human Strong By screening a HeLa cell cDNA library using an adenovirus ATF-binding sequence as the probe, the authors isolated cDNAs encoding ATF7, which they called ATFA, and a splice variant. Gwenael Breard
[11278933] DNA Binding Mouse Strong ATF-7 is most closely related to members of the ATF/CREB family of bZIP proteins, with highest homology to ATF-4. ATF-7 homodimers can bind specifically to CRE elements. Gwenael Breard
[15735663] TF PPI Human Strong Athors show that overexpression of hsTAF12 potentiates ATF7-induced transcriptional activation through direct interaction with ATF7, suggesting that TAF12 is a functional partner of ATF7. In support of this conclusion, chromatin immunoprecipitation experiments confirm the interaction of ATF7 with TAF12 on an ATF7-responsive promoter, in the absence of any artificial overexpression of both proteins. Gwenael Breard
Additional Reviewer Comments:
Reviewer: Gwenael Breard

The ATF7 proteins, which are members of the cyclic AMP responsive binding protein (CREB)/activating transcription factor (ATF) family of transcription factors, display quite versatile properties: they can interact with the adenovirus E1a oncoprotein, mediating part of its transcriptional activity; they heterodimerize with the Jun, Fos or related transcription factors, likely modulating their DNA-binding specificity; they also recruit to the promoter a stress-induced protein kinase (JNK2) and bind TAF12.


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Facts about Atf7 223922RDF feed
Gene description activating transcription factor 7  +
Gene id 223,922  +
Gene judgment TF Gene  +
Gene symbol atf7  +, 1110012F10Rik  +, 9430065F09Rik  +, AI549878  +, C130020M04Rik  +, and MGC31554  +
Gene taxonomy DNA-Binding: sequence-specific  +
Homolog cluster 107,503  +
Protein family 3 Zipper-Type Group/21 Leucine Zipper Family  +
Protein group 3 Zipper-Type Group   +
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