Atf7 223922

From TFCatWiki

Jump to: navigation, search

External Links

Gene ID: 223922
Gene symbol: atf7
Gene Description: activating transcription factor 7
Aliases: 1110012F10Rik; 9430065F09Rik; AI549878; C130020M04Rik; MGC31554
Human Ortholog Gene ID: [11016]
Reviewer Judgement: TF Gene
Functional Classification: DNA-Binding: sequence-specific
DBD Protein Group Classification: Zipper-Type Group
DBD Protein Group/Family Classification: Zipper-Type Group / Leucine Zipper Family
Homolog Cluster(s): 107503


Pubmed ID Function Species Evidence Strength Reviewer's Comments Reviewer
[11278933] DNA Binding Mouse Strong EMSA assays show that ATF-7 can bind to CRE elements. Co-immunoprecipitation experiments show that ATF-7 also binds to PRL-1 and that this interaction allows PRL-1 to dephosphorylate ATF-7 Sarav Sundararajan
[15735663] Transactivation Human Strong Reporter assays show that the GAL4(DBD)-ATF-7 fusion can transactivate the UAS-luciferase construct and that this transactivation is mediated through interactions between ATF-7 and hsTAF12. Sarav Sundararajan
[1694576] DNA Binding Human Strong By screening a HeLa cell cDNA library using an adenovirus ATF-binding sequence as the probe, the authors isolated cDNAs encoding ATF7, which they called ATFA, and a splice variant. Gwenael Breard
[11278933] DNA Binding Mouse Strong ATF-7 is most closely related to members of the ATF/CREB family of bZIP proteins, with highest homology to ATF-4. ATF-7 homodimers can bind specifically to CRE elements. Gwenael Breard
[15735663] TF PPI Human Strong Athors show that overexpression of hsTAF12 potentiates ATF7-induced transcriptional activation through direct interaction with ATF7, suggesting that TAF12 is a functional partner of ATF7. In support of this conclusion, chromatin immunoprecipitation experiments confirm the interaction of ATF7 with TAF12 on an ATF7-responsive promoter, in the absence of any artificial overexpression of both proteins. Gwenael Breard
Additional Reviewer Comments:
Reviewer: Gwenael Breard

The ATF7 proteins, which are members of the cyclic AMP responsive binding protein (CREB)/activating transcription factor (ATF) family of transcription factors, display quite versatile properties: they can interact with the adenovirus E1a oncoprotein, mediating part of its transcriptional activity; they heterodimerize with the Jun, Fos or related transcription factors, likely modulating their DNA-binding specificity; they also recruit to the promoter a stress-induced protein kinase (JNK2) and bind TAF12.

DISCUSSION PAGE link for this gene

VIEW gene annotation feedback in the [TFCat Annotation Feedback Reports Inquiry]

REPORT gene annotation feedback on the [TFCat Annotation Feedback Reporting System] Help is available here

The section below defines information for semantic searching. Please see the help page for more information on this section.

Facts about Atf7 223922RDF feed
Gene description activating transcription factor 7  +
Gene id 223,922  +
Gene judgment TF Gene  +
Gene symbol atf7  +, 1110012F10Rik  +, 9430065F09Rik  +, AI549878  +, C130020M04Rik  +, and MGC31554  +
Gene taxonomy DNA-Binding: sequence-specific  +
Homolog cluster 107,503  +
Protein family 3 Zipper-Type Group/21 Leucine Zipper Family  +
Protein group 3 Zipper-Type Group   +
Personal tools