Atf7ip 54343

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Gene ID: 54343
Gene symbol: atf7ip
Gene Description: activating transcription factor 7 interacting protein
Aliases: 2610204M12Rik; AM; Mcaf1
Human Ortholog Gene ID: [55729]
Reviewer Judgement: TF Gene
Functional Classification: Transcription Factor Binding: tf co-factor binding
Homolog Cluster(s): 54343

Evidence:

Pubmed ID Function Species Evidence Strength Reviewer's Comments Reviewer
[10777215] Co-activation; TF PPI Mouse Weak yeast 2-hybrid screen with ATFa pulls down this protein; subsequent co-localization screen shows they are in the same place in cells; ATPase activity measured Wyeth Wasserman
[14536086] Co-activation; TF PPI Human Medium ESET/SETDB1 is a histone methyltransferase (HMTase). Here, we show that SETDB1 tightly associates with the human homolog of mAM.

promoter H3-K9 trimethylation causes transcriptional repression; mAM/hAM facilitates conversion of H3-K9 dimethyl to trimethyl by ESET/SETDB1

Wyeth Wasserman
Additional Reviewer Comments:
Reviewer: Wyeth Wasserman

aka mAM (mouse ATFa-associated Modulator) It colocalizes and interacts with ATFa in mammalian cells, contains a bipartite nuclear localization signal and possesses an ATPase activity. PMID 10777215 atp-ase activity; colocalization with atfa; Y2H interaction with ATFa


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Facts about Atf7ip 54343RDF feed
Gene description activating transcription factor 7 interacting protein  +
Gene id 54,343  +
Gene judgment TF Gene  +
Gene symbol atf7ip  +, 2610204M12Rik  +, AM  +, and Mcaf1  +
Gene taxonomy Transcription Factor Binding: tf co-factor binding  +
Homolog cluster 54,343  +
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