Atm 11920

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Gene ID: 11920
Gene symbol: atm
Gene Description: ataxia telangiectasia mutated homolog (human)
Aliases: AI256621; C030026E19Rik
Human Ortholog Gene ID: [472]
Reviewer Judgement: TF Gene Candidate
Functional Classification: Transcription Factor Binding: tf co-factor binding
Homolog Cluster(s): 11920

Evidence:

Pubmed ID Function Species Evidence Strength Reviewer's Comments Reviewer
[12496286] Co-activation; DNA Binding Mouse Medium In cerebral, cerebellar, and hepatic tissue from ATM (-/-) double knockout mice, using EMSA the DNA-binding activity of transcription factor AP-1 was found to be increased relative to the equivalent tissues from ATM (+/+) mice.

In cerebellum from ATM (-/-) double knockout mice, through immunoblotting of nuclear extracts protein expression of transcription factors c-fos and c-jun was increased relative to equivalent tissues from ATM (+/+).

In cerebrum from ATM (-/-) double knockout mice, through immunoblotting of nuclear extracts protein expression of transcription factors c-fos was increased relative to equivalent tissues from ATM (+/+).

Stuart Lithwick
[16461339] DNA Binding Human Strong Through serial fractionation of human Raji cells, it was determined that association of ATM with chromatin increases after exposure to ionizing radiation. Stuart Lithwick
[16644862] Transactivation Mouse Medium In calvarial osteoblasts from a ATM (-/-) double knockout mouse, using semi-quantitative RT-PCR a marked decrease in the expression level of osterix, a transcription factor critical for osteoblast differentiation, was observed, while the expression level of other similar transcription factors remained constant. Stuart Lithwick
Additional Reviewer Comments:
Reviewer: Stuart Lithwick

ATM is likely a negative regulator of other transcription factors. EMSA assays indicate that association of transcription factor AP-1 with DNA is increased in ATM double-knockout mice relative to wild type. As well, increased mRNA expression of transcription factor osterix, and increased protein expression of transcription factors c-fos and c-jun is observed in ATM double knockout mice relative to wild type. Interaction of ATM with chromatin is observed through the fractionation of Raji cells, but only in the context of DNA repair, after exposure to ionizing radiation. It looks as though it gets to DNA by binding to double-strand break binding proteins (PMID 15758953) WWW.


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Facts about Atm 11920RDF feed
Gene description ataxia telangiectasia mutated homolog (human)  +
Gene id 11,920  +
Gene judgment TF Gene Candidate  +
Gene symbol atm  +, AI256621  +, and C030026E19Rik  +
Gene taxonomy Transcription Factor Binding: tf co-factor binding  +
Homolog cluster 11,920  +
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