Bag1 12017

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Gene ID: 12017
Gene symbol: bag1
Gene Description: bcl2-associated athanogene 1
Aliases: Rap46
Human Ortholog Gene ID: [573]
Reviewer Judgement: TF Gene
Functional Classification: Transcription Factor Binding: tf co-factor binding
Homolog Cluster(s): 12017

Evidence:

Pubmed ID Function Species Evidence Strength Reviewer's Comments Reviewer
[9642262] TF PPI Mouse Strong Gel retardation assays using cell extracts from CV-1 cells demonstrate that in vitro translated BAG-1 protein can effectively inhibit the binding of RAR (retinoic acid receptor) to a number of retinoic acid response elements. BAG-1 is shown to interact with RAR in an in vitro GST pull-down assay and in a yeast two-hybrid assay. Amy Ticoll
[11101523] TF PPI Human Strong Addition of GST�RAP46 (Bag1) to an EMSA with extracts from COS-7 cells transfected with the GR (glucocorticoid receptor) inhibits DNA binding by the receptor. This possibly makes use of the Hsc70 in the extract. The inhibitory effect is specific: not observed with GST alone or with the deletion of the Hsp70/Hsc70 binding site in RAP46. Amy Ticoll
Additional Reviewer Comments:
Reviewer: Amy Ticoll

Addition of GST–RAP46 (Bag1) to an EMSA with extracts from cells transfected with the GR inhibits DNA binding by the receptor. BAG-1 is shown to interact with RAR in an in vitro GST pull-down assay and in a yeast two-hybrid assay. In transient transfection assays (CV-1 cells), co-transfection of BAG-1 expression plasmid inhibits the transactivation activity of RAR/RXR heterodimers.


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Facts about Bag1 12017RDF feed
Gene description bcl2-associated athanogene 1  +
Gene id 12,017  +
Gene judgment TF Gene  +
Gene symbol bag1  +, and Rap46  +
Gene taxonomy Transcription Factor Binding: tf co-factor binding  +
Homolog cluster 12,017  +
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