Bhlhb3 79362

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Gene ID: 79362
Gene symbol: bhlhb3
Gene Description: basic helix-loop-helix domain containing, class b3
Aliases: Bhlhb2l; DEC2; Sharp1
Human Ortholog Gene ID: [79365]
Reviewer Judgement: TF Gene
Functional Classification: Transcription Factor Binding: tf co-factor binding;

DNA-Binding: sequence-specific

DBD Protein Group Classification: Zipper-Type Group
DBD Protein Group/Family Classification: Zipper-Type Group / Helix-Loop-Helix Family
Homolog Cluster(s): 15206

Evidence:

Pubmed ID Function Species Evidence Strength Reviewer's Comments Reviewer
[12657651] Other; DNA Binding Mouse Strong DNA binding determined by EMSA.

Transcriptional repression is determined by transient co-transfections.

David Martin
[15448136] TF PPI Unknown Strong PPI : C3H10T1/2 cells were transfected with expression vectors for MyoD or E47 individually and together with myc-Sharp-1. Cell lysates were immunoprecipitated with anti-myc antibody and subjected to Western blot analysis with either anti-MyoD or anti-E47 antibodies.

Transcriptional repressor : when coupled to MyoD or E47, Sharp1 blocks the transactivation.

David Martin
Additional Reviewer Comments:


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Facts about Bhlhb3 79362RDF feed
Gene description basic helix-loop-helix domain containing, class b3  +
Gene id 79,362  +
Gene judgment TF Gene  +
Gene symbol bhlhb3  +, Bhlhb2l  +, DEC2  +, and Sharp1  +
Gene taxonomy Transcription Factor Binding: tf co-factor binding  +, and DNA-Binding: sequence-specific  +
Homolog cluster 15,206  +
Protein family 3 Zipper-Type Group/22 Helix-Loop-Helix Family  +
Protein group 3 Zipper-Type Group   +
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