Bmi1 12151

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Gene ID: 12151
Gene symbol: bmi1
Gene Description: bmi1 polycomb ring finger oncogene
Aliases: AW546694; Bmi-1; Pcgf4
Human Ortholog Gene ID: [648]
Reviewer Judgement: TF Gene
Functional Classification: Transcription Regulatory Activity: heterochromatin interaction/binding
Homolog Cluster(s): 12151

Evidence:

Pubmed ID Function Species Evidence Strength Reviewer's Comments Reviewer
[1823128] DNA Binding Mouse Weak DNA-binding activity was initially suggested by the presence of the RING-type (C3HC4) zinc finger domain. However, there appears to be no evidence for direct binding to DNA. Tim Hughes
[10500182] TF PPI Mouse Unknown The RING finger is now known to be a protein-protein interaction domain that mediates ubiquitin-conjugating enzyme (E2)-dependent ubiquitination. Tim Hughes
[15386022] Other Other Unknown Bmi1-containing complex monoubiquitinates nucleosomal histone H2A at lysine 119. Tim Hughes
Additional Reviewer Comments:
Reviewer: Tim Hughes

This gene encodes a PcG component (i.e. a component of the polycomb complex). There is ample evidence for a function in heterochromatin and gene regulation. DNA-binding activity was initially suggested by the presence of the RING-type (C3HC4) zinc finger domain (PMID: 1823128). However, there appears to be no evidence for direct binding to DNA. Rather, the RING finger is now known to be a protein-protein interaction domain that mediates ubiquitin-conjugating enzyme (E2)-dependent ubiquitination (PMID: 10500182). Consistent with this, a Bmi1-containing complex monoubiquitinates nucleosomal histone H2A at lysine 119 (PMID: 15386022).


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Facts about Bmi1 12151RDF feed
Gene description bmi1 polycomb ring finger oncogene  +
Gene id 12,151  +
Gene judgment TF Gene  +
Gene symbol bmi1  +, AW546694  +, Bmi-1  +, and Pcgf4  +
Gene taxonomy Transcription Regulatory Activity: heterochromatin interaction/binding  +
Homolog cluster 12,151  +
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