Bptf 207165

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Gene ID: 207165
Gene symbol: bptf
Gene Description: bromodomain phd finger transcription factor
Aliases: 9430093H17Rik; Falz; MGC54978
Human Ortholog Gene ID: [2186]
Reviewer Judgement: TF Gene
Functional Classification: Transcription Factor Binding: tf co-factor binding;

DNA-Binding: sequence-specific

DBD Protein Group Classification: Unclassified Structure
DBD Protein Group/Family Classification: Unclassified Structure / DNA binding homeobox and Different Transcription Factors (DDT) Domain Family
Homolog Cluster(s): 207165

Evidence:

Pubmed ID Function Species Evidence Strength Reviewer's Comments Reviewer
[10575013] DNA Binding Human Strong A DNA sequence specifically recognized by recombinant FAC1 is identified by the polymerase chain reaction-assisted binding site selection assay. Specific binding of recombinant and endogenous FAC (in MSN-2 and PC12 cells) to the FBE is confirmed in competitive EMSA studies. In NIH3T3 cells, luciferase reporter plasmids containing the identified binding site (CACAACAC) are repressed by cotransfected FAC1. Amy Ticoll
[10727212] TF PPI Human Medium FAC1 interacts with the myc-associated zinc finger protein (ZF87/MAZ) as shown in a two-hybrid yeast screen and GST pull-down assay. Immunoblotting of epitope-tagged ZF87/MAZ transfected in PT67 cells shows in vivo produced ZF87/MAZ interacts with FAC1. FAC1 reduces transcriptional activation of the SV40 promoter by ZF87/MAZ in NIH3T3 cells transfected with reporter vector. Amy Ticoll
Additional Reviewer Comments:
Reviewer: Amy Ticoll

FAC1 (Falz) is shown to interact with DNA and nuclear proteins. EMSA studies confirm FAC binds specifically to a DNA sequence identified by the polymerase chain reaction-assisted binding site selection assay. Luciferase reporter plasmids containing the binding site are repressed by cotransfected FAC1. Two-hybrid yeast screen, GST pull-down assay, and immunoblotting confirm that. FAC1 interacts with the myc-associated zinc finger protein (ZF87/MAZ). FAC1 reduces transcriptional activation of the SV40 promoter by ZF87/MAZ as shown by reporter assay.


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Facts about Bptf 207165RDF feed
Gene description bromodomain phd finger transcription factor  +
Gene id 207,165  +
Gene judgment TF Gene  +
Gene symbol bptf  +, 9430093H17Rik  +, Falz  +, and MGC54978  +
Gene taxonomy Transcription Factor Binding: tf co-factor binding  +, and DNA-Binding: sequence-specific  +
Homolog cluster 207,165  +
Protein family 999 Unclassified Structure/903 DNA binding homeobox and Different Transcription Factors (DDT) Domain Family  +
Protein group 999 Unclassified Structure   +
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