Brd7 26992

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Gene ID: 26992
Gene symbol: brd7
Gene Description: bromodomain containing 7
Aliases: BP75; CELTIX1; Ptpn13ip
Human Ortholog Gene ID: [29117]
Reviewer Judgement: TF Gene
Functional Classification: Transcription Regulatory Activity: heterochromatin interaction/binding
Homolog Cluster(s): 14534


Pubmed ID Function Species Evidence Strength Reviewer's Comments Reviewer
[12489984] Co-activation Unknown Strong "Using yeast two-hybrid screening, we identified a novel chromatin-associated bromodomain-containing protein, BRD7, as an E1B-AP5 interaction partner. We confirmed E1B-AP5-BRD7 complex formation in vivo and in vitro. We found that, although BRD7 binds to histones H2A, H2B, H3 and H4 through its bromodomain, this domain was not necessary for the interaction with E1B-AP5. Indeed, the triple complex formation of E1B-AP5, BRD7 and histones was demonstrated. Disruption of the E1B-AP5-BRD7 complex increased E1B-AP5 repression activity for basic transcription and converted it from being an activator of the hormone-dependent promoter into being a strong repressor. We conclude that complex formation between BRD7 and E1B-AP5 links chromatin events with mRNA processing at the level of transcriptional regulation." Jared Roach
Additional Reviewer Comments:
Reviewer: Jared Roach

This is on the line between "candidate" and certainty, but based on the abstract of PMID 12489984, I will classify it as a TF that functions through heterochromatin interaction.

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Facts about Brd7 26992RDF feed
Gene description bromodomain containing 7  +
Gene id 26,992  +
Gene judgment TF Gene  +
Gene symbol brd7  +, BP75  +, CELTIX1  +, and Ptpn13ip  +
Gene taxonomy Transcription Regulatory Activity: heterochromatin interaction/binding  +
Homolog cluster 14,534  +
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