Cdc6 23834

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Gene ID: 23834
Gene symbol: cdc6
Gene Description: cell division cycle 6 homolog (s. cerevisiae)
Aliases: CDC18L
Human Ortholog Gene ID: [990]
Reviewer Judgement: TF Gene Candidate
Functional Classification: Transcription Regulatory Activity: heterochromatin interaction/binding
Homolog Cluster(s): 23834

Evidence:

Pubmed ID Function Species Evidence Strength Reviewer's Comments Reviewer
[14667810] DNA Binding Mouse Medium Mouse Cdc6 was found to interact with chromatin in chromatin binding assays in which whole cell or nuclear extracts of 2B, 2E, and C1 cell lines (CHO-DUKX cell lines with multiple copies of the mouse Cdc6 gene stably introduced within a BAC clone), supernatant and chromatin fractions were isolated, purified, and then immunoblotted using anti Cdc6. Mouse Cdc6 was also enriched in the nuclear fraction relative to the whole cell extract for all three cell types. Stuart Lithwick
Additional Reviewer Comments:
Reviewer: Stuart Lithwick

Cdc6 may be involved in transcription given its ability to interact with chromatin and its subcellular localization. Recombinant mouse Cdc6 protein stably introduced into CHO cells binds to chromatin and is enriched somewhat in nuclear fractions relative to whole cell extracts as demonstrated by immunoblotting using anti-Cdc6. However, Cdc6 is more frequently associated with the regulation of DNA replication and cell cycle control (PMID: 10575231)


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Facts about Cdc6 23834RDF feed
Gene description cell division cycle 6 homolog (s. cerevisiae)  +
Gene id 23,834  +
Gene judgment TF Gene Candidate  +
Gene symbol cdc6  +, and CDC18L  +
Gene taxonomy Transcription Regulatory Activity: heterochromatin interaction/binding  +
Homolog cluster 23,834  +
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