Cdk7 12572

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Gene ID: 12572
Gene symbol: cdk7
Gene Description: cyclin-dependent kinase 7 (homolog of xenopus mo15 cdk-activating kinase)
Aliases: AI323415; AI528512; Cdkn7; Crk4
Human Ortholog Gene ID: [1022]
Reviewer Judgement: TF Gene Candidate
Functional Classification:
Homolog Cluster(s): 107951

Evidence:

Pubmed ID Function Species Evidence Strength Reviewer's Comments Reviewer
[7566158] Co-activation Human Strong CDK7 phosphorylates the RNA Polymerase II carboxy terminal doamin and is required for transcriptional activation of the DHFR promoter but not the AdML promoter in an in vitro transcription assay. Evidence suggested that CTD phosphoylation was not required for transcription initiation but was required for either promoter clearance or transcript elongation. Rob Sladek
[7761469] Co-activation Human Strong CDK7 phosphorylates the carboxy terminal domain (CTD) of RNA Polymerase II. TFIIH complexes containtaining kinase-deficient mutants of CDK7 have reduced CTD phosphorylation but do not alter gal4-VP16 induction of transcription using an in vitro transcription assay. Rob Sladek
[12379213] Co-activation Human Medium CDK7 is a component of the TFIIH complex.

CDK7 enhanced dexamethasone-stimulated MMTV promoter activity in HeLa and A204 cells in cotransfection assays.

Rob Sladek
Additional Reviewer Comments:
Reviewer: Rob Sladek

CDK7 is a component of the TFIIH complex. CDK7 phosphorylates the carboxy terminal domain (CTD) of RNA Polymerase II. TFIIH complexes containtaining kinase-deficient mutants of CDK7 have reduced CTD phosphorylation and display promoter-specific effects on gene transcription. For example, CDK7 required for transcriptional activation of the DHFR promoter but not the AdML promoter in an in vitro transcription assay.


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Facts about Cdk7 12572RDF feed
Gene description cyclin-dependent kinase 7 (homolog of xenopus mo15 cdk-activating kinase)  +
Gene id 12,572  +
Gene judgment TF Gene Candidate  +
Gene symbol cdk7  +, AI323415  +, AI528512  +, Cdkn7  +, and Crk4  +
Homolog cluster 107,951  +
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