Cdkn1a 12575

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Gene ID: 12575
Gene symbol: cdkn1a
Gene Description: cyclin-dependent kinase inhibitor 1a (p21)
Aliases: CAP20; CDKI; Cdkn1; CIP1; mda6; P21; p21Cip1; p21WAF; SDI1; Waf1
Human Ortholog Gene ID: [1026]
Reviewer Judgement: TF Gene
Functional Classification: Transcription Factor Binding: tf co-factor binding
Homolog Cluster(s): 12575


Pubmed ID Function Species Evidence Strength Reviewer's Comments Reviewer
[15743834] DNA Binding Human Strong ChIP assays in MCF-7 cells indicate p21 is recruited to the PR promoter in an estrogen-dependent manner. Amy Ticoll
Additional Reviewer Comments:
Reviewer: Amy Ticoll

ChIP assays indicate p21 is recruited to the endogenous estrogen target gene PR promoter. Transfection assays in MCF-7 cells show p21 coactivates endogenous ERα target genes in a gene-specific manner. Forms foci at sites of DNA damage (PMID 11779358). It arrives at foci late in the process (PMID 16551699) and does not apear to be the DNA binding protein - seems to be protein-protein interaction but not conclusive. WWW

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Facts about Cdkn1a 12575RDF feed
Gene description cyclin-dependent kinase inhibitor 1a (p21)  +
Gene id 12,575  +
Gene judgment TF Gene  +
Gene symbol cdkn1a  +, CAP20  +, CDKI  +, Cdkn1  +, CIP1  +, mda6  +, P21  +, p21Cip1  +, p21WAF  +, SDI1  +, and Waf1  +
Gene taxonomy Transcription Factor Binding: tf co-factor binding  +
Homolog cluster 12,575  +
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