Cdkn2a 12578

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Gene ID: 12578
Gene symbol: cdkn2a
Gene Description: cyclin-dependent kinase inhibitor 2a
Aliases: Arf; ARF-INK4a; INK4a-ARF; MTS1; p16; p16(INK4a); p16INK4a; p19ARF; Pctr1
Human Ortholog Gene ID: [60468]
Reviewer Judgement: TF Gene
Functional Classification: Transcription Factor Binding: tf co-factor binding
Homolog Cluster(s): 12051

Evidence:

Pubmed ID Function Species Evidence Strength Reviewer's Comments Reviewer
[15361825] DNA Binding Human Strong p14ARF is shown to cosediment with chromatin-associated proteins in human 293 cell lines. ChIP assay demonstrates association of p14ARF specifically with human rRNA gene promoter. Experiments conducted with adequate controls. Amy Ticoll
[16924243] Transactivation Human Medium Transfection assays in H348wt cells show that p14ARF negatively regulates rRNA transcription. Amy Ticoll
Additional Reviewer Comments:
Reviewer: Amy Ticoll

ChIP assay demonstrates association of p14ARF specifically with human rRNA gene promoter. Transfection assays show that p14ARF negatively regulates rRNA transcription. It appears to me to be a protein-protein interaction with topoisomerases that brings this protein to the DNA - not DNA binding - no strong evidence. WWW


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Facts about Cdkn2a 12578RDF feed
Gene description cyclin-dependent kinase inhibitor 2a  +
Gene id 12,578  +
Gene judgment TF Gene  +
Gene symbol cdkn2a  +, Arf  +, ARF-INK4a  +, INK4a-ARF  +, MTS1  +, p16  +, p16(INK4a)  +, p16INK4a  +, p19ARF  +, and Pctr1  +
Gene taxonomy Transcription Factor Binding: tf co-factor binding  +
Homolog cluster 12,051  +
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