Cdx1 12590

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Gene ID: 12590
Gene symbol: cdx1
Gene Description: caudal type homeo box 1
Aliases: Cdx; Cdx-1
Human Ortholog Gene ID: [1044]
Reviewer Judgement: TF Gene
Functional Classification: DNA-Binding: sequence-specific
DBD Protein Group Classification: Helix-Turn-Helix Group
DBD Protein Group/Family Classification: Helix-Turn-Helix Group / Homeodomain Family
Homolog Cluster(s): 103889

Evidence:

Pubmed ID Function Species Evidence Strength Reviewer's Comments Reviewer
[15677472] DNA Binding Human; Mouse Strong EMSA experiments using mouse duodenal nuclear extracts and oligonucleotides corresponding to the Cbx1 binding site from the human ADA duodenal enhancer show that Cbx1 can bind to its binding element and that mutation of this element abrogates binding. Sarav Sundararajan
[15774940] Transactivation Human Strong Luciferase reporter constructs using driven by varying lengths of the human IAP promoter show that Cbx1 can transactivate this promoter. Sarav Sundararajan
[7585967] Transactivation Mouse Strong Cdx1 activates Hox-A7 in transient transfection studies performed in P19 embryonal carcinoma cells. Rob Sladek
[12954759] DNA Binding Human Strong CDX1 binds specifically to the TATA box of the rat G6Pase (glucose-6-phosphatase) gene promoter in gel shift assays performed using HeLa cells transiently transfected with a CDX1 expression vector. CDX1 activates this promoter in transient transfection studies perfromed in HepG2 cells. Rob Sladek
Additional Reviewer Comments:
Reviewer: Rob Sladek

Cdx1 activates Hox-A7 in transient transfection studies performed in P19 embryonal carcinoma cells. CDX1 binds specifically to the TATA box of the rat G6Pase (glucose-6-phosphatase) gene promoter in gel shift assays performed using HeLa cells transiently transfected with a CDX1 expression vector. CDX1 activates this promoter in transient transfection studies performed in HepG2 cells.


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Facts about Cdx1 12590RDF feed
Gene description caudal type homeo box 1  +
Gene id 12,590  +
Gene judgment TF Gene  +
Gene symbol cdx1  +, Cdx  +, and Cdx-1  +
Gene taxonomy DNA-Binding: sequence-specific  +
Homolog cluster 103,889  +
Protein family 1.1 Helix-Turn-Helix Group/2 Homeodomain Family  +
Protein group 1.1 Helix-Turn-Helix Group   +
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