Cdx2 12591

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Gene ID: 12591
Gene symbol: cdx2
Gene Description: caudal type homeo box 2
Aliases: Cdx-2
Human Ortholog Gene ID: [1045]
Reviewer Judgement: TF Gene
Functional Classification: DNA-Binding: sequence-specific
DBD Protein Group Classification: Helix-Turn-Helix Group
DBD Protein Group/Family Classification: Helix-Turn-Helix Group / Homeodomain Family
Homolog Cluster(s): 103889

Evidence:

Pubmed ID Function Species Evidence Strength Reviewer's Comments Reviewer
[7935448] DNA Binding; Transactivation Mouse Strong Cdx2 expressed in rabbit reticulocyte lysates shows high affinity monomeric and dimeric binding to the SIF1 (sucrose-isomaltase gene footprint 1) element in gel shift assays. This element contains two 7 base pair long A/T-rich half sites which closely match the consensus binding site identified for the chicken CHox-cad (CdxA) protein.

Cdx2 activated transcription mediated by the sucrose-isomaltase gene promoter in transiently transfected HepG2 hepatocellular carcinoma cells. Cdx2 transactivation was abolished following mutation of the SIF1 element.

Rob Sladek
Additional Reviewer Comments:
Reviewer: Rob Sladek

Cdx2 expressed in rabbit reticulocyte lysates shows high affinity monomeric and dimeric binding to the SIF1 (sucrose-isomaltase gene footprint 1) element in gel shift assays. This element contains two 7 base pair long A/T-rich half sites which closely match the consensus binding site identified for the chicken CHox-cad (CdxA) protein. Cdx2 activated transcription mediated by the sucrose-isomaltase gene promoter in transiently transfected HepG2 hepatocellular carcinoma cells. Cdx2 transactivation was abolished following mutation of the SIF1 element.


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Facts about Cdx2 12591RDF feed
Gene description caudal type homeo box 2  +
Gene id 12,591  +
Gene judgment TF Gene  +
Gene symbol cdx2  +, and Cdx-2  +
Gene taxonomy DNA-Binding: sequence-specific  +
Homolog cluster 103,889  +
Protein family 1.1 Helix-Turn-Helix Group/2 Homeodomain Family  +
Protein group 1.1 Helix-Turn-Helix Group   +
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