Cebpa 12606

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Gene ID: 12606
Gene symbol: cebpa
Gene Description: ccaat/enhancer binding protein (c/ebp), alpha
Aliases: CBF-A; Cebp
Human Ortholog Gene ID: [1050]
Reviewer Judgement: TF Gene
Functional Classification: DNA-Binding: sequence-specific
DBD Protein Group Classification: Zipper-Type Group
DBD Protein Group/Family Classification: Zipper-Type Group / Leucine Zipper Family
Homolog Cluster(s): 107503

Evidence:

Pubmed ID Function Species Evidence Strength Reviewer's Comments Reviewer
[2227417] Transactivation Rat Strong Cebpa activates the rat albumin gene promoter: specific transactivation domains were identified by studying Cebpa deletion mutants. Rob Sladek
[8632009] DNA Binding Rat Strong Binding site selection studies using a purified bacterially expressed GST-Cebpa fusion protein identified a consensus Cebpa binding sequence (5'-RTTGCGYAAY-3'). The interaction between Cebpa and the consensus site was confirmed in gel shift assays. Rob Sladek
Additional Reviewer Comments:
Reviewer: Rob Sladek

Binding site selection studies using a purified bacterially expressed GST-Cebpa fusion protein identified a consensus Cebpa binding sequence (5'-RTTGCGYAAY-3'). The interaction between Cebpa and the consensus site was confirmed in gel shift assays. Cebpa activates the rat albumin gene promoter: specific transactivation domains have been identified by studying Cebpa deletion mutants.


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Facts about Cebpa 12606RDF feed
Gene description ccaat/enhancer binding protein (c/ebp), alpha  +
Gene id 12,606  +
Gene judgment TF Gene  +
Gene symbol cebpa  +, CBF-A  +, and Cebp  +
Gene taxonomy DNA-Binding: sequence-specific  +
Homolog cluster 107,503  +
Protein family 3 Zipper-Type Group/21 Leucine Zipper Family  +
Protein group 3 Zipper-Type Group   +
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