Cebpd 12609

From TFCatWiki

Jump to: navigation, search

External Links

Gene ID: 12609
Gene symbol: cebpd
Gene Description: ccaat/enhancer binding protein (c/ebp), delta
Human Ortholog Gene ID: [1052]
Reviewer Judgement: TF Gene
Functional Classification: DNA-Binding: sequence-specific
DBD Protein Group Classification: Zipper-Type Group
DBD Protein Group/Family Classification: Zipper-Type Group / Leucine Zipper Family
Homolog Cluster(s): 107503


Pubmed ID Function Species Evidence Strength Reviewer's Comments Reviewer
[8572170] DNA Binding; Transactivation Human; Rat Strong Supershift EMSA assays of C/EBP{delta} expressed in COS-1 cells using anti-C/EBP{delta} antibody with NHE1 C/EBP binding site using rat liver nuclear extracts demonstrates protein/DNA binding. Cotransfection of Hep G2 and VSM A7r5 cells with the NHEl promoter-CAT reporter (plasmid) and an expression vector for C/EBP-delta demonsrate stimulation of significant transcriptional activity. Debra Fulton
[16192306] Other Mouse Medium In the absence of C/EBP{delta}, multiprobe ribonuclease protection assay (in total RNA from mammary glands) and Northern analysis indicate that regulation of the pro-apoptotic genes Bak on Inv d1 and Bax on Inv d2 was impaired in mutant C/EBP{delta} deficient glands. Transfection of non-transformed mouse MEC line HC11 with C/EBP{delta} expression vectors elicit a growth arrest response in HC11 cells with upregulation of Gas1 mRNA levels and C/EBP{delta} alone was able to induce expression of SGP2 and IGFBP5, and inhibited expression of Cyclin D1. Debra Fulton
Additional Reviewer Comments:
Reviewer: Debra Fulton

C/EBP{delta" is a transcription factor that bind a conserved C/EBP DNA binding site as demonstrated by supershift EMSA assays and transactivates NHE1 gene regulation as shown by NHE1-promoter-CAT assays.

DISCUSSION PAGE link for this gene

VIEW gene annotation feedback in the [TFCat Annotation Feedback Reports Inquiry]

REPORT gene annotation feedback on the [TFCat Annotation Feedback Reporting System] Help is available here

The section below defines information for semantic searching. Please see the help page for more information on this section.

Facts about Cebpd 12609RDF feed
Gene description ccaat/enhancer binding protein (c/ebp), delta  +
Gene id 12,609  +
Gene judgment TF Gene  +
Gene symbol cebpd  +
Gene taxonomy DNA-Binding: sequence-specific  +
Homolog cluster 107,503  +
Protein family 3 Zipper-Type Group/21 Leucine Zipper Family  +
Protein group 3 Zipper-Type Group   +
Personal tools