Cebpd 12609

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Gene ID: 12609
Gene symbol: cebpd
Gene Description: ccaat/enhancer binding protein (c/ebp), delta
Aliases:
Human Ortholog Gene ID: [1052]
Reviewer Judgement: TF Gene
Functional Classification: DNA-Binding: sequence-specific
DBD Protein Group Classification: Zipper-Type Group
DBD Protein Group/Family Classification: Zipper-Type Group / Leucine Zipper Family
Homolog Cluster(s): 107503

Evidence:

Pubmed ID Function Species Evidence Strength Reviewer's Comments Reviewer
[8572170] DNA Binding; Transactivation Human; Rat Strong Supershift EMSA assays of C/EBP{delta} expressed in COS-1 cells using anti-C/EBP{delta} antibody with NHE1 C/EBP binding site using rat liver nuclear extracts demonstrates protein/DNA binding. Cotransfection of Hep G2 and VSM A7r5 cells with the NHEl promoter-CAT reporter (plasmid) and an expression vector for C/EBP-delta demonsrate stimulation of significant transcriptional activity. Debra Fulton
[16192306] Other Mouse Medium In the absence of C/EBP{delta}, multiprobe ribonuclease protection assay (in total RNA from mammary glands) and Northern analysis indicate that regulation of the pro-apoptotic genes Bak on Inv d1 and Bax on Inv d2 was impaired in mutant C/EBP{delta} deficient glands. Transfection of non-transformed mouse MEC line HC11 with C/EBP{delta} expression vectors elicit a growth arrest response in HC11 cells with upregulation of Gas1 mRNA levels and C/EBP{delta} alone was able to induce expression of SGP2 and IGFBP5, and inhibited expression of Cyclin D1. Debra Fulton
Additional Reviewer Comments:
Reviewer: Debra Fulton

C/EBP{delta" is a transcription factor that bind a conserved C/EBP DNA binding site as demonstrated by supershift EMSA assays and transactivates NHE1 gene regulation as shown by NHE1-promoter-CAT assays.


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Facts about Cebpd 12609RDF feed
Gene description ccaat/enhancer binding protein (c/ebp), delta  +
Gene id 12,609  +
Gene judgment TF Gene  +
Gene symbol cebpd  +
Gene taxonomy DNA-Binding: sequence-specific  +
Homolog cluster 107,503  +
Protein family 3 Zipper-Type Group/21 Leucine Zipper Family  +
Protein group 3 Zipper-Type Group   +
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