Cebpe 110794

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Gene ID: 110794
Gene symbol: cebpe
Gene Description: ccaat/enhancer binding protein (c/ebp), epsilon
Aliases: C/EBPe; CRP1; Gm294; MGC124002; MGC124003
Human Ortholog Gene ID: [1053]
Reviewer Judgement: TF Gene
Functional Classification: Transcription Factor Binding: tf co-factor binding;

DNA-Binding: sequence-specific

DBD Protein Group Classification: Zipper-Type Group
DBD Protein Group/Family Classification: Zipper-Type Group / Leucine Zipper Family
Homolog Cluster(s): 107503

Evidence:

Pubmed ID Function Species Evidence Strength Reviewer's Comments Reviewer
[9593684] Transactivation Mouse Weak upregulation of several genes in presence of cebpe overexpression Wyeth Wasserman
[10233885] DNA Binding; Transactivation; TF PPI Mouse Strong binding affinity for target sites, comparing epsillon versus alpha proteins

binding site in: neutrophil elastase binding site in : mim-1

interaction with myb-1

Wyeth Wasserman
Additional Reviewer Comments:
Reviewer: Wyeth Wasserman

role of C/EBP(epsilon) in the terminal stages of granulocyte differentiation [PMID 11239167 ] A short conserved motif is required for repressor domain function in the myeloid-specific transcription factor CCAAT/enhancer-binding protein epsilon. [PMID 9933609] CCAAT/enhancer binding protein epsilon is preferentially up-regulated during granulocytic differentiation and its functional versatility is determined by alternative use of promoters and differential splicing [PMID 9177240] SELEX for other members of the fmaily, but not this protein[PMID 8632009]


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Facts about Cebpe 110794RDF feed
Gene description ccaat/enhancer binding protein (c/ebp), epsilon  +
Gene id 110,794  +
Gene judgment TF Gene  +
Gene symbol cebpe  +, C/EBPe  +, CRP1  +, Gm294  +, MGC124002  +, and MGC124003  +
Gene taxonomy Transcription Factor Binding: tf co-factor binding  +, and DNA-Binding: sequence-specific  +
Homolog cluster 107,503  +
Protein family 3 Zipper-Type Group/21 Leucine Zipper Family  +
Protein group 3 Zipper-Type Group   +
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