Cebpz 12607

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Gene ID: 12607
Gene symbol: cebpz
Gene Description: ccaat/enhancer binding protein zeta
Aliases: AI848081; Cbf; CBF2; Cebpa-rs1; MGC36087
Human Ortholog Gene ID: [10153]
Reviewer Judgement: TF Gene
Functional Classification: Transcription Factor Binding: tf co-factor binding
Homolog Cluster(s): 12607

Evidence:

Pubmed ID Function Species Evidence Strength Reviewer's Comments Reviewer
[2247079] DNA Binding Human Strong EMSA assays indicate CBF binds specifically to the CCAAT element of the hsp70 promoter. Experiments conducted with appropriate controls. Results confirmed with exonuclease III protection assays. Amy Ticoll
Additional Reviewer Comments:
Reviewer: Amy Ticoll

EMSA and exonuclease III protection assays indicate CBF binds specifically to the CCAAT element of the hsp70 promoter. Expression of CBF cDNA activates transcription from cotransfected hsp70 promoter-reporter gene constructs in a CCAAT-dependent manner. The evidence in PMID 17513780 is not very convincing. They claim that they have extracted everything else so the only protein that could be binding to a sequence is Zeta but never prove it. PMID 8622660 shows that CHOP10 blocks dna binding by ATF3 when they form a complex. Trace back to original paper PMID 1547942 showing CHOP10 blocks DNA binding by several TFs. WWW


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Facts about Cebpz 12607RDF feed
Gene description ccaat/enhancer binding protein zeta  +
Gene id 12,607  +
Gene judgment TF Gene  +
Gene symbol cebpz  +, AI848081  +, Cbf  +, CBF2  +, Cebpa-rs1  +, and MGC36087  +
Gene taxonomy Transcription Factor Binding: tf co-factor binding  +
Homolog cluster 12,607  +
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