Ciita 12265

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Gene ID: 12265
Gene symbol: ciita
Gene Description: class ii transactivator
Aliases: C2ta; MGC130299
Human Ortholog Gene ID: [4261]
Reviewer Judgement: TF Gene
Functional Classification: Transcription Factor Binding: tf co-factor binding
Homolog Cluster(s): 12265

Evidence:

Pubmed ID Function Species Evidence Strength Reviewer's Comments Reviewer
[12506036] DNA Binding; Transactivation Unknown Strong transcription of MHC Jared Roach
Additional Reviewer Comments:
Reviewer: Jared Roach

From the human EntrezGene Entry: "This gene encodes a protein with an acidic transcriptional activation domain, 4 LRRs (leucine-rich repeats) and a GTP binding domain. The protein is located in the nucleus and acts as a positive regulator of class II major histocompatibility complex gene transcription, and is referred to as the "master control factor" for the expression of these genes. The protein also binds GTP and uses GTP binding to facilitate its own transport into the nucleus. Once in the nucleus it does not bind DNA but rather uses an intrinsic acetyltransferase (AT) activity to act in a coactivator-like fashion."


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Facts about Ciita 12265RDF feed
Gene description class ii transactivator  +
Gene id 12,265  +
Gene judgment TF Gene  +
Gene symbol ciita  +, C2ta  +, and MGC130299  +
Gene taxonomy Transcription Factor Binding: tf co-factor binding  +
Homolog cluster 12,265  +
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