Clock 12753

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Gene ID: 12753
Gene symbol: clock
Gene Description: circadian locomoter output cycles kaput
Aliases: 5330400M04Rik; mKIAA0334
Human Ortholog Gene ID: [9575]
Reviewer Judgement: TF Gene
Functional Classification: DNA-Binding: sequence-specific
DBD Protein Group Classification: Zipper-Type Group
DBD Protein Group/Family Classification: Zipper-Type Group / Helix-Loop-Helix Family
Homolog Cluster(s): 11622; 15206


Pubmed ID Function Species Evidence Strength Reviewer's Comments Reviewer
[9616112] DNA Binding Mouse Medium Yeast one hybrid results showing a specific binding of the heterodimer CLOCK-BMAL1 capable of inducing transcription from E-box elements Gwenael Breard
[15147242] Co-activation Mouse Strong Results suggest that the Clock/Bmal heterodimer enhances Dec2 transcription via the CACGTG E-boxes Gwenael Breard
[15500444] Other Mouse Not Selected CLOCK plays an important role in lipid homoeostasis by regulating the transcription of a key protein, PPARalpha Gwenael Breard
Additional Reviewer Comments:
Reviewer: Gwenael Breard

The mouse Clock gene encodes a bHLH-PAS protein that regulates circadian rhythms and is related to transcription factors that act as heterodimers.

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Facts about Clock 12753RDF feed
Gene description circadian locomoter output cycles kaput  +
Gene id 12,753  +
Gene judgment TF Gene  +
Gene symbol clock  +, 5330400M04Rik  +, and mKIAA0334  +
Gene taxonomy DNA-Binding: sequence-specific  +
Homolog cluster 11,622  +, and 15,206  +
Protein family 3 Zipper-Type Group/22 Helix-Loop-Helix Family  +
Protein group 3 Zipper-Type Group   +
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