Clock 12753

From TFCatWiki

Jump to: navigation, search

External Links

Gene ID: 12753
Gene symbol: clock
Gene Description: circadian locomoter output cycles kaput
Aliases: 5330400M04Rik; mKIAA0334
Human Ortholog Gene ID: [9575]
Reviewer Judgement: TF Gene
Functional Classification: DNA-Binding: sequence-specific
DBD Protein Group Classification: Zipper-Type Group
DBD Protein Group/Family Classification: Zipper-Type Group / Helix-Loop-Helix Family
Homolog Cluster(s): 11622; 15206

Evidence:

Pubmed ID Function Species Evidence Strength Reviewer's Comments Reviewer
[9616112] DNA Binding Mouse Medium Yeast one hybrid results showing a specific binding of the heterodimer CLOCK-BMAL1 capable of inducing transcription from E-box elements Gwenael Breard
[15147242] Co-activation Mouse Strong Results suggest that the Clock/Bmal heterodimer enhances Dec2 transcription via the CACGTG E-boxes Gwenael Breard
[15500444] Other Mouse Not Selected CLOCK plays an important role in lipid homoeostasis by regulating the transcription of a key protein, PPARalpha Gwenael Breard
Additional Reviewer Comments:
Reviewer: Gwenael Breard

The mouse Clock gene encodes a bHLH-PAS protein that regulates circadian rhythms and is related to transcription factors that act as heterodimers.


DISCUSSION PAGE link for this gene

VIEW gene annotation feedback in the [TFCat Annotation Feedback Reports Inquiry]

REPORT gene annotation feedback on the [TFCat Annotation Feedback Reporting System] Help is available here


The section below defines information for semantic searching. Please see the help page for more information on this section.

Facts about Clock 12753RDF feed
Gene description circadian locomoter output cycles kaput  +
Gene id 12,753  +
Gene judgment TF Gene  +
Gene symbol clock  +, 5330400M04Rik  +, and mKIAA0334  +
Gene taxonomy DNA-Binding: sequence-specific  +
Homolog cluster 11,622  +, and 15,206  +
Protein family 3 Zipper-Type Group/22 Helix-Loop-Helix Family  +
Protein group 3 Zipper-Type Group   +
Personal tools