Cops2 12848

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Gene ID: 12848
Gene symbol: cops2
Gene Description: cop9 (constitutive photomorphogenic) homolog, subunit 2 (arabidopsis thaliana)
Aliases: AI315723; alien-like; C85265; Csn2; Sgn2; Trip15
Human Ortholog Gene ID: [9318]
Reviewer Judgement: TF Gene
Functional Classification: Transcription Factor Binding: tf co-factor binding
Homolog Cluster(s): 12848

Evidence:

Pubmed ID Function Species Evidence Strength Reviewer's Comments Reviewer
[10991940] TF PPI Mouse Strong Interferon consensus sequence-binding protein (ICSBP) exerts some of its transcriptional activities via association with other factors. Assays of yeast two-hybrid, in vitro glutathione S-transferase pull-down and coimmunoprecipitation (in COS7 cells) indicate Trip15 is a specific interacting factor of ICSBP. Kinase assays demonstrate in vitro association of ICSBP with the CSN leads to phosphorylation of ICSBP at a unique serine residue, which is essential for efficient association with IRF-1. Amy Ticoll
[12522100] TF PPI Mouse Strong Mouse Nif3l1 participates in retinoic acid-primed neural differentiation of P19 embryonic carcinoma cells through cooperation with Trip15/CSN2. Interaction between Nif3l1 and Trip15/CSN2 is confirmed through yeast two-hybrid screening (P19 cell cDNA library), pull-down assay and epitope-tagged coimmunoprecipitation. A luciferase reporter assay in P19 cells shows the action of Nif3l1 as a transcriptional repressor is augmented by Trip15/CSN2. Amy Ticoll
Additional Reviewer Comments:
Reviewer: Amy Ticoll

Cops2 is a member of the COP9 signalosome complex. The signalosome has transcription regulatory activity (PMIDs:15451666,11114242,16943200). Yeast two-hybrid, pull-down and coimmunoprecipitation assays indicate that Cops2 interacts specifically with the transcription factors ICSBP and Nif3l1. Kinase assays demonstrate in vitro association of ICSBP with the CSN leads to phosphorylation of ICSBP at a unique serine residue, which is essential for efficient association with IRF-1. A reporter assay shows the action of Nif3l1 as a transcriptional repressor is augmented by Trip15/CSN2.


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Facts about Cops2 12848RDF feed
Gene description cop9 (constitutive photomorphogenic) homolog, subunit 2 (arabidopsis thaliana)  +
Gene id 12,848  +
Gene judgment TF Gene  +
Gene symbol cops2  +, AI315723  +, alien-like  +, C85265  +, Csn2  +, Sgn2  +, and Trip15  +
Gene taxonomy Transcription Factor Binding: tf co-factor binding  +
Homolog cluster 12,848  +
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