Creb3l1 26427

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Gene ID: 26427
Gene symbol: creb3l1
Gene Description: camp responsive element binding protein 3-like 1
Aliases: MGC25246; Oasis
Human Ortholog Gene ID: [90993]
Reviewer Judgement: TF Gene
Functional Classification: DNA-Binding: sequence-specific
DBD Protein Group Classification: Zipper-Type Group
DBD Protein Group/Family Classification: Zipper-Type Group / Leucine Zipper Family
Homolog Cluster(s): 107503


Pubmed ID Function Species Evidence Strength Reviewer's Comments Reviewer
[15665855] DNA Binding Human Strong OASIS, a CREB/ATF-family member, modulates UPR signalling in astrocytes. Gwenael Breard
[16236796] Other Human Unknown Oasis localizes to the ER membrane Gwenael Breard
Additional Reviewer Comments:
Reviewer: Gwenael Breard

OASIS is a basic leucine zipper (bZIP) transcription factor of the CREB/ATF family with a transmembrane domain that allows it to associate with the ER. The molecule is cleaved at the membrane in response to ER stress, and its cleaved amino-terminal cytoplasmic domain, which contains the bZIP domain, translocates into the nucleus where it activates the transcription of target genes that are mediated by ER stress-responsive and cyclic AMP-responsive elements.

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Facts about Creb3l1 26427RDF feed
Gene description camp responsive element binding protein 3-like 1  +
Gene id 26,427  +
Gene judgment TF Gene  +
Gene symbol creb3l1  +, MGC25246  +, and Oasis  +
Gene taxonomy DNA-Binding: sequence-specific  +
Homolog cluster 107,503  +
Protein family 3 Zipper-Type Group/21 Leucine Zipper Family  +
Protein group 3 Zipper-Type Group   +
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