Creb3l4 78284

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Gene ID: 78284
Gene symbol: creb3l4
Gene Description: camp responsive element binding protein 3-like 4
Aliases: 1700012K17Rik; 5330432F22Rik; AIBZIP; Atce1; AV040530; AV258827; CREB3; CREB4; JAL; mJAL; TISP40; Tisp40alpha; Tisp40beta
Human Ortholog Gene ID: [148327]
Reviewer Judgement: TF Gene
Functional Classification: DNA-Binding: sequence-specific
DBD Protein Group Classification: Zipper-Type Group
DBD Protein Group/Family Classification: Zipper-Type Group / Leucine Zipper Family
Homolog Cluster(s): 107503

Evidence:

Pubmed ID Function Species Evidence Strength Reviewer's Comments Reviewer
[11956138] DNA Binding Mouse Strong Creb3l4 (Atce1) synthesized in rabbit reticoulcyte lysates binds to the NF-kappaB response element in gel shift assay. Rob Sladek
[15938716] DNA Binding; Transactivation Mouse Strong Creb3l4 (Tisp40) synthesized in rabbit reticoulcyte lysates binds to the unfolded protein response element (UPRE) in gel shift assay.

An aciidic domain in Creb3l4 activates transcription as a GAL4-DBD fusion protein following transient transfection in HeLa S3 cells. Creb3l4 activated transcription from a UPRE-containing reporter plasmid following transient transfection in HeLa S3 cells.

In these studies the Tisp40beta isoform showed transcriptional activity while the Tisp40alpha isoform was inactive (this isoform lacks the acidic domain).

Rob Sladek
Additional Reviewer Comments:
Reviewer: Rob Sladek

Creb3l4 synthesized in rabbit reticoulcyte lysates binds to the unfolded protein response element (UPRE) and the NF-kappaB response element in gel shift assay. An aciidic domain in Creb3l4 activates transcription as a GAL4-DBD fusion protein following transient transfection in HeLa S3 cells. Full length Creb3l4 (Tisp40beta) activated transcription from a UPRE-containing reporter plasmid following transient transfection in HeLa S3 cells. Creb3l4 isoforms lacking the acidic activation domain (Tispa40alpha) have been coloned from mouse testis where it is expressed in spermatids.


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Facts about Creb3l4 78284RDF feed
Gene description camp responsive element binding protein 3-like 4  +
Gene id 78,284  +
Gene judgment TF Gene  +
Gene symbol creb3l4  +, 1700012K17Rik  +, 5330432F22Rik  +, AIBZIP  +, Atce1  +, AV040530  +, AV258827  +, CREB3  +, CREB4  +, JAL  +, mJAL  +, TISP40  +, Tisp40alpha  +, and Tisp40beta  +
Gene taxonomy DNA-Binding: sequence-specific  +
Homolog cluster 107,503  +
Protein family 3 Zipper-Type Group/21 Leucine Zipper Family  +
Protein group 3 Zipper-Type Group   +
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