Crebbp 12914

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Gene ID: 12914
Gene symbol: crebbp
Gene Description: creb binding protein
Aliases: AW558298; CBP; CBP/p300
Human Ortholog Gene ID: [1387]
Reviewer Judgement: TF Gene Candidate
Functional Classification:
Homolog Cluster(s): 12914

Evidence:

Pubmed ID Function Species Evidence Strength Reviewer's Comments Reviewer
[8413673] Co-activation Mouse Strong A partial CBP clone was isolated from a human thyroid expression library screened with phosphorylated CREB. The full length clone was assembled from cDNA clones obtained by screening a mouse brain library.

Southwestern blotting shows that bacterially-expressed CBP fragments bind specifically to CREB phosphorylated by PKA.

A fusion protein containing the CBP amino terminus (AA 1-400) linked to the GAL4-DBD expresses transcription of a UASGAL4-CAT reporter following transient transfection of F9 teratocarcinoma cells.

Rob Sladek
Additional Reviewer Comments:
Reviewer: Rob Sladek

A partial CBP clone was isolated from a human thyroid expression library screened with phosphorylated CREB. The full length clone was assembled from cDNA clones obtained by screening a mouse brain library. Southwestern blotting shows that bacterially-expressed CBP fragments bind specifically to CREB phosphorylated by PKA. A fusion protein containing the CBP amino terminus (AA 1-400) linked to the GAL4-DBD expresses transcription of a UASGAL4-CAT reporter following transient transfection of F9 teratocarcinoma cells.


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Facts about Crebbp 12914RDF feed
Gene description creb binding protein  +
Gene id 12,914  +
Gene judgment TF Gene Candidate  +
Gene symbol crebbp  +, AW558298  +, CBP  +, and CBP/p300  +
Homolog cluster 12,914  +
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