Creg1 433375

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Gene ID: 433375
Gene symbol: creg1
Gene Description: cellular repressor of e1a-stimulated genes 1
Aliases: AA755314; Creg
Human Ortholog Gene ID: [8804]
Reviewer Judgement: TF Gene Candidate
Functional Classification: Transcription Factor Binding: tf co-factor binding
Homolog Cluster(s): 433375

Evidence:

Pubmed ID Function Species Evidence Strength Reviewer's Comments Reviewer
[9710587] DNA Binding Human Strong The adenovirus E1A protein both activates and represses gene expression to promote cellular proliferation and inhibit differentiation. Authors report the identification and characterization of a cellular protein that antagonizes transcriptional activation and cellular transformation by E1A. This protein, termed CREG for cellular repressor of E1A-stimulated genes, shares limited sequence similarity with E1A and binds both the general transcription factor TBP and the tumor suppressor pRb in vitro. In transfection assays, CREG represses transcription and antagonizes 12SE1A-mediated activation of both the adenovirus E2 and cellular hsp70 promoters. CREG also antagonizes E1A-mediated transformation, as expression of CREG reduces the efficiency with which E1A and the oncogene ras cooperate to transform primary cells. Binding sites for E2F, a key transcriptional regulator of cell cycle progression, were found to be required for repression of the adenovirus E2 promoter by CREG, and CREG was shown to inhibit activation by E2F. Gwenael Breard
Additional Reviewer Comments:
Reviewer: Gwenael Breard

the protein CREG for cellular repressor of E1A-stimulated genes, shares limited sequence similarity with E1A and binds both the general transcription factor TBP and the tumor suppressor pRb in vitro. In transfection assays, CREG represses transcription and antagonizes 12SE1A-mediated activation of both the adenovirus E2 and cellular hsp70 promoters.


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Facts about Creg1 433375RDF feed
Gene description cellular repressor of e1a-stimulated genes 1  +
Gene id 433,375  +
Gene judgment TF Gene Candidate  +
Gene symbol creg1  +, AA755314  +, and Creg  +
Gene taxonomy Transcription Factor Binding: tf co-factor binding  +
Homolog cluster 433,375  +
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