Crx 12951

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Gene ID: 12951
Gene symbol: crx
Gene Description: cone-rod homeobox containing gene
Aliases: Crx1
Human Ortholog Gene ID: [1406]
Reviewer Judgement: TF Gene
Functional Classification: DNA-Binding: sequence-specific
DBD Protein Group Classification: Helix-Turn-Helix Group
DBD Protein Group/Family Classification: Helix-Turn-Helix Group / Homeodomain Family
Homolog Cluster(s): 103889

Evidence:

Pubmed ID Function Species Evidence Strength Reviewer's Comments Reviewer
[15001570] DNA Binding; Transactivation Human Strong CRX binds specific binding sites in the PDE6A promoter (DNase I footprinting, EMSA).

CRX transactivate the PDE6A promoter in a gene reporter assay.

Elodie Portales-Casamar
[16332268] DNA Binding Mouse Strong chIP assay to identify CRX (and other photoreceptor specific factors) DNA targets. Elodie Portales-Casamar
Additional Reviewer Comments:
Reviewer: Elodie Portales-Casamar

CRX binds specific sites upstream photoreceptor specific genes and activates their transcription. Very strong evidences.


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Facts about Crx 12951RDF feed
Gene description cone-rod homeobox containing gene  +
Gene id 12,951  +
Gene judgment TF Gene  +
Gene symbol crx  +, and Crx1  +
Gene taxonomy DNA-Binding: sequence-specific  +
Homolog cluster 103,889  +
Protein family 1.1 Helix-Turn-Helix Group/2 Homeodomain Family  +
Protein group 1.1 Helix-Turn-Helix Group   +
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