Ctbp1 13016

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Gene ID: 13016
Gene symbol: ctbp1
Gene Description: c-terminal binding protein 1
Aliases: BARS; CtBP1-L; CtBP1-S; CtBP3/BARS; D4S115h; D5H4S115; D5H4S115E
Human Ortholog Gene ID: [1487]
Reviewer Judgement: TF Gene Candidate
Functional Classification: Transcription Factor Binding: tf co-factor binding
Homolog Cluster(s): 13016

Evidence:

Pubmed ID Function Species Evidence Strength Reviewer's Comments Reviewer
[10567582] Co-activation Mouse Medium Ctbp1 expressed as a fusion protein containing the Gal4-DBD represses a 4xGAL-TK-Luc reporter gene in transiently transfected C3H-10T1/2 cells.

Ctbp1 repressed expression of a reporter containing four copies of the E2-box element when cotransfected with delta-EF1 in C3H-10T1/2 cells.

Rob Sladek
[15834423] Co-activation Mouse Strong Ctbp1 increases transactivation of a (5xGal4)-luciferase reporter following transient transfection of VP16-GAL4DBD into murine embryo fibroblasts obtained from Ctbp1(+/-) and Ctbp1(-/-) transgenic mice.

Ctbp1 interacts with the p300 bromodomain and controls p300-mediated histone acetylation.

The protein used in the study is likely murine as a subsequent paper by the same authors stated that pGEX-CtBP1 was made using a mouse IMAGE clone (PMID: 16326862).

Rob Sladek
Additional Reviewer Comments:
Reviewer: Rob Sladek

Ctbp1 interacts with the p300 bromodomain and controls p300-mediated histone acetylation. Ctbp1 increases transactivation of a (5xGal4)-luciferase reporter following transient transfection of VP16-GAL4DBD into murine embryo fibroblasts obtained from Ctbp1(+/-) and Ctbp1(-/-) transgenic mice. Ctbp1 repressed expression of a reporter containing four copies of the E2-box element when cotransfected with delta-EF1 in C3H-10T1/2 cells.


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Facts about Ctbp1 13016RDF feed
Gene description c-terminal binding protein 1  +
Gene id 13,016  +
Gene judgment TF Gene Candidate  +
Gene symbol ctbp1  +, BARS  +, CtBP1-L  +, CtBP1-S  +, CtBP3/BARS  +, D4S115h  +, D5H4S115  +, and D5H4S115E  +
Gene taxonomy Transcription Factor Binding: tf co-factor binding  +
Homolog cluster 13,016  +
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