Ctbp2 13017

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Gene ID: 13017
Gene symbol: ctbp2
Gene Description: c-terminal binding protein 2
Aliases: AA407280; D7Ertd45e; Ribeye
Human Ortholog Gene ID: [1488]
Reviewer Judgement: TF Gene
Functional Classification: Transcription Factor Binding: tf co-factor binding
Homolog Cluster(s): 13016

Evidence:

Pubmed ID Function Species Evidence Strength Reviewer's Comments Reviewer
[11504872] TF PPI Other; Mouse Strong Fgf-3 promoter-binding protein SOX6 is shown to bind to CtBP2 in a yeast two-hybrid screen. Immunoprecipitation from Cos7 cells followed by immunoblotting confirms the interaction between SOX6 and CtBP2. Amy Ticoll
Additional Reviewer Comments:
Reviewer: Amy Ticoll

Yeast two-hybrid and immunoprecipitation analyses indicate that CtBP2 binds the DNA-binding protein SOX6. Reporter assays using both dF9 and NIH3T3 cells demonstrate that SOX6 must recruit CtBP2 to repress the activity of the Fgf-3 promoter.


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Facts about Ctbp2 13017RDF feed
Gene description c-terminal binding protein 2  +
Gene id 13,017  +
Gene judgment TF Gene  +
Gene symbol ctbp2  +, AA407280  +, D7Ertd45e  +, and Ribeye  +
Gene taxonomy Transcription Factor Binding: tf co-factor binding  +
Homolog cluster 13,016  +
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