Cux1 13047

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Gene ID: 13047
Gene symbol: cux1
Gene Description: cut-like homeobox 1
Aliases: AA407197; CDP; Cux; Cux-1; Cux1; KIAA4047; MGC102214; mKIAA4047; Phox2
Human Ortholog Gene ID: [1523]
Reviewer Judgement: TF Gene
Functional Classification: DNA-Binding: sequence-specific
DBD Protein Group Classification: Helix-Turn-Helix Group
DBD Protein Group/Family Classification: Helix-Turn-Helix Group / Homeodomain Family
Homolog Cluster(s): 103889; 109181

Evidence:

Pubmed ID Function Species Evidence Strength Reviewer's Comments Reviewer
[10864926] DNA Binding Other Strong Results revealed that cooperation between various CDP/CUT DNA-binding domains can generate at least two DNA-binding activities with distinct binding kinetics and specificities. On one hand, CR1 and CR2 bind rapidly but transiently to sequences containing two C(A/G)AT sites in either orientation. On the other hand, CR3 and the CUT homeodomain can form a stable complex with the ATCGAT DNA sequence. Gwenael Breard
[15994318] DNA Binding Mouse Strong Electrophoretic mobility shift assays demonstrated that the 3'-half of DER (DER2) was targeted by the repressor CCAAT-displacement protein (CDP)/Cux. Chromatin immunoprecipitation experiments further demonstrated in vivo CDP-DER association in the blastocyst and the 8.5 day embryo. Furthermore, the DER-dependent repression was partially relieved in vivo in co-transfection with an antisense CDP construct Gwenael Breard
Additional Reviewer Comments:
Reviewer: Gwenael Breard

CDP is a repressor of transcription. Its differents DNA-binding domains modules and biochemical properties have been well deciphered and characterized Moon et al.


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Facts about Cux1 13047RDF feed
Gene description cut-like homeobox 1  +
Gene id 13,047  +
Gene judgment TF Gene  +
Gene symbol cux1  +, AA407197  +, CDP  +, Cux  +, Cux-1  +, Cux1  +, KIAA4047  +, MGC102214  +, mKIAA4047  +, and Phox2  +
Gene taxonomy DNA-Binding: sequence-specific  +
Homolog cluster 103,889  +, and 109,181  +
Protein family 1.1 Helix-Turn-Helix Group/2 Homeodomain Family  +
Protein group 1.1 Helix-Turn-Helix Group   +
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