Cux1 13047

From TFCatWiki

Jump to: navigation, search

External Links

Gene ID: 13047
Gene symbol: cux1
Gene Description: cut-like homeobox 1
Aliases: AA407197; CDP; Cux; Cux-1; Cux1; KIAA4047; MGC102214; mKIAA4047; Phox2
Human Ortholog Gene ID: [1523]
Reviewer Judgement: TF Gene
Functional Classification: DNA-Binding: sequence-specific
DBD Protein Group Classification: Helix-Turn-Helix Group
DBD Protein Group/Family Classification: Helix-Turn-Helix Group / Homeodomain Family
Homolog Cluster(s): 103889; 109181


Pubmed ID Function Species Evidence Strength Reviewer's Comments Reviewer
[10864926] DNA Binding Other Strong Results revealed that cooperation between various CDP/CUT DNA-binding domains can generate at least two DNA-binding activities with distinct binding kinetics and specificities. On one hand, CR1 and CR2 bind rapidly but transiently to sequences containing two C(A/G)AT sites in either orientation. On the other hand, CR3 and the CUT homeodomain can form a stable complex with the ATCGAT DNA sequence. Gwenael Breard
[15994318] DNA Binding Mouse Strong Electrophoretic mobility shift assays demonstrated that the 3'-half of DER (DER2) was targeted by the repressor CCAAT-displacement protein (CDP)/Cux. Chromatin immunoprecipitation experiments further demonstrated in vivo CDP-DER association in the blastocyst and the 8.5 day embryo. Furthermore, the DER-dependent repression was partially relieved in vivo in co-transfection with an antisense CDP construct Gwenael Breard
Additional Reviewer Comments:
Reviewer: Gwenael Breard

CDP is a repressor of transcription. Its differents DNA-binding domains modules and biochemical properties have been well deciphered and characterized Moon et al.

DISCUSSION PAGE link for this gene

VIEW gene annotation feedback in the [TFCat Annotation Feedback Reports Inquiry]

REPORT gene annotation feedback on the [TFCat Annotation Feedback Reporting System] Help is available here

The section below defines information for semantic searching. Please see the help page for more information on this section.

Facts about Cux1 13047RDF feed
Gene description cut-like homeobox 1  +
Gene id 13,047  +
Gene judgment TF Gene  +
Gene symbol cux1  +, AA407197  +, CDP  +, Cux  +, Cux-1  +, Cux1  +, KIAA4047  +, MGC102214  +, mKIAA4047  +, and Phox2  +
Gene taxonomy DNA-Binding: sequence-specific  +
Homolog cluster 103,889  +, and 109,181  +
Protein family 1.1 Helix-Turn-Helix Group/2 Homeodomain Family  +
Protein group 1.1 Helix-Turn-Helix Group   +
Personal tools