Cux2 13048

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Gene ID: 13048
Gene symbol: cux2
Gene Description: cut-like homeobox 2
Aliases: Cux-2; Cux2; ENSMUSG00000072641
Human Ortholog Gene ID: [23316]
Reviewer Judgement: TF Gene
Functional Classification: DNA-Binding: sequence-specific
DBD Protein Group Classification: Helix-Turn-Helix Group
DBD Protein Group/Family Classification: Helix-Turn-Helix Group / Homeodomain Family
Homolog Cluster(s): 103889; 109181

Evidence:

Pubmed ID Function Species Evidence Strength Reviewer's Comments Reviewer
[8798433] DNA Binding Mouse Medium GST-Cux-2 fusion proteins specifically bound the Ncam promoter sequence in EMSA. Experiments conducted with appropriate controls. Amy Ticoll
[15656993] DNA Binding Human; Mouse Strong Immunofluorescence analysis indicates Cux2 is localized in the nucleus. Cux2 antibodies are able to supershift CDP2/Cux2 protein´┐ŻDNA complexes in EMSA with nuclear extracts from NIH 3T3, HeLa cells, and HS578T cells. Reporter assays indicate Cux2 can function as a transcriptional repressor. Amy Ticoll
Additional Reviewer Comments:
Reviewer: Amy Ticoll

Immunofluorescence analysis indicates Cux2 is localized in the nucleus. EMSA indicates Cux2 binds specific promoter sequences. Reporter assays indicate Cux2 can function as a transcriptional repressor.


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Facts about Cux2 13048RDF feed
Gene description cut-like homeobox 2  +
Gene id 13,048  +
Gene judgment TF Gene  +
Gene symbol cux2  +, Cux-2  +, Cux2  +, and ENSMUSG00000072641  +
Gene taxonomy DNA-Binding: sequence-specific  +
Homolog cluster 103,889  +, and 109,181  +
Protein family 1.1 Helix-Turn-Helix Group/2 Homeodomain Family  +
Protein group 1.1 Helix-Turn-Helix Group   +
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