Ddit3 13198

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Gene ID: 13198
Gene symbol: ddit3
Gene Description: dna-damage inducible transcript 3
Aliases: chop; CHOP-10; CHOP10; gadd153
Human Ortholog Gene ID: [1649]
Reviewer Judgement: TF Gene
Functional Classification: Transcription Factor Binding: tf co-factor binding;

DNA-Binding: sequence-specific

DBD Protein Group Classification: Zipper-Type Group
DBD Protein Group/Family Classification: Zipper-Type Group / Leucine Zipper Family
Homolog Cluster(s): 107503

Evidence:

Pubmed ID Function Species Evidence Strength Reviewer's Comments Reviewer
[8657121] Co-activation Mouse Strong Competition in DNase I footprint assays and methylation interference demonstrate sequence-specific binding of CHOP-C/EBP dimers (NIH 3T3 cells). Deletions in the basic region of CHOP (Ddit3) leads to loss of DNA binding. Amy Ticoll
Additional Reviewer Comments:
Reviewer: Amy Ticoll

DNase I footprint assays and methylation interference demonstrate sequence-specific binding of CHOP-C/EBP dimers. Deletions in the basic region of CHOP (Ddit3) leads to loss of DNA binding. Transfection assays suggest CHOP is a transactivator.


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Facts about Ddit3 13198RDF feed
Gene description dna-damage inducible transcript 3  +
Gene id 13,198  +
Gene judgment TF Gene  +
Gene symbol ddit3  +, chop  +, CHOP-10  +, CHOP10  +, and gadd153  +
Gene taxonomy Transcription Factor Binding: tf co-factor binding  +, and DNA-Binding: sequence-specific  +
Homolog cluster 107,503  +
Protein family 3 Zipper-Type Group/21 Leucine Zipper Family  +
Protein group 3 Zipper-Type Group   +
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