Dlx2 13392

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Gene ID: 13392
Gene symbol: dlx2
Gene Description: distal-less homeobox 2
Aliases: AW121999; Dlx-2; Tes-1
Human Ortholog Gene ID: [1746]
Reviewer Judgement: TF Gene
Functional Classification: DNA-Binding: sequence-specific
DBD Protein Group Classification: Helix-Turn-Helix Group
DBD Protein Group/Family Classification: Helix-Turn-Helix Group / Homeodomain Family
Homolog Cluster(s): 103889

Evidence:

Pubmed ID Function Species Evidence Strength Reviewer's Comments Reviewer
[9415433] DNA Binding Mouse Medium Gel mobility shift assay with NP and WIP oligos indicate that DLX-2 bind to them. Binding to NP was abolished when competed with nonradioactive NP. Andrew Kwon
[14769946] DNA Binding; Transactivation Mouse Strong Optimized ChIP shows that DLX2 binds to Dlx5/6 intergenic enhancer in situ. EMSA shows that DLX2 binds to this region in vitro. DLX2 contransfected with the enhancer-linked reporter activates its expression. Site-directed mutagenesis of the TAAT motif in the enhancer greatly reduces reporter activation by DLX2. Andrew Kwon
Additional Reviewer Comments:
Reviewer: Andrew Kwon

ChIP and EMSA show that DLX2 binds to specific DNA motif, and transfection study with intact and mutant motif shows that DLX2 only activates expression with the intact motif. Based on the evidence, DLX2 is a transcription factor.


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Facts about Dlx2 13392RDF feed
Gene description distal-less homeobox 2  +
Gene id 13,392  +
Gene judgment TF Gene  +
Gene symbol dlx2  +, AW121999  +, Dlx-2  +, and Tes-1  +
Gene taxonomy DNA-Binding: sequence-specific  +
Homolog cluster 103,889  +
Protein family 1.1 Helix-Turn-Helix Group/2 Homeodomain Family  +
Protein group 1.1 Helix-Turn-Helix Group   +
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