Dlx3 13393

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Gene ID: 13393
Gene symbol: dlx3
Gene Description: distal-less homeobox 3
Aliases: AV237891; Dlx-3
Human Ortholog Gene ID: [1747]
Reviewer Judgement: TF Gene
Functional Classification: DNA-Binding: sequence-specific
DBD Protein Group Classification: Helix-Turn-Helix Group
DBD Protein Group/Family Classification: Helix-Turn-Helix Group / Homeodomain Family
Homolog Cluster(s): 103889; 104360


Pubmed ID Function Species Evidence Strength Reviewer's Comments Reviewer
[16687405] DNA Binding; TF PPI Human Medium EMSA studies using nuclear extracts and antiserum against Dlx3 indicates endogenous Dlx3 can bind to a specific site in the Esx1 gene promoter. Amy Ticoll
Additional Reviewer Comments:
Reviewer: Amy Ticoll

EMSA studies indicate Dlx3 can bind to a specific site in the Esx1 gene promoter. Dlx3 overexpression increases Esx1 luciferase activity in transfection assays (JEG3 cells).

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Facts about Dlx3 13393RDF feed
Gene description distal-less homeobox 3  +
Gene id 13,393  +
Gene judgment TF Gene  +
Gene symbol dlx3  +, AV237891  +, and Dlx-3  +
Gene taxonomy DNA-Binding: sequence-specific  +
Homolog cluster 103,889  +, and 104,360  +
Protein family 1.1 Helix-Turn-Helix Group/2 Homeodomain Family  +
Protein group 1.1 Helix-Turn-Helix Group   +
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