Dlx4 13394

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Gene ID: 13394
Gene symbol: dlx4
Gene Description: distal-less homeobox 4
Aliases: Dlx-4; Dlx7; MGC129167
Human Ortholog Gene ID: [1748]
Reviewer Judgement: TF Gene
Functional Classification: DNA-Binding: sequence-specific
DBD Protein Group Classification: Helix-Turn-Helix Group
DBD Protein Group/Family Classification: Helix-Turn-Helix Group / Homeodomain Family
Homolog Cluster(s): 103889

Evidence:

Pubmed ID Function Species Evidence Strength Reviewer's Comments Reviewer
[11909945] DNA Binding Human Medium EMSA indicates both in vitro synthesized and K562 cell-extracted BP1 (Dlx4) binds specifically to the BP1 binding site in silencer I. Amy Ticoll
Additional Reviewer Comments:
Reviewer: Amy Ticoll

EMSA indicates BP1 (Dlx4) binds specifically to the BP1 binding site in silencer I. Transient transfection assays performed in K562 cells show BP1 represses the beta-globin promoter.


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Facts about Dlx4 13394RDF feed
Gene description distal-less homeobox 4  +
Gene id 13,394  +
Gene judgment TF Gene  +
Gene symbol dlx4  +, Dlx-4  +, Dlx7  +, and MGC129167  +
Gene taxonomy DNA-Binding: sequence-specific  +
Homolog cluster 103,889  +
Protein family 1.1 Helix-Turn-Helix Group/2 Homeodomain Family  +
Protein group 1.1 Helix-Turn-Helix Group   +
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