Dlx5 13395

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Gene ID: 13395
Gene symbol: dlx5
Gene Description: distal-less homeobox 5
Aliases: AI385752
Human Ortholog Gene ID: [1749]
Reviewer Judgement: TF Gene
Functional Classification: DNA-Binding: sequence-specific
DBD Protein Group Classification: Helix-Turn-Helix Group
DBD Protein Group/Family Classification: Helix-Turn-Helix Group / Homeodomain Family
Homolog Cluster(s): 103889

Evidence:

Pubmed ID Function Species Evidence Strength Reviewer's Comments Reviewer
[15383550] DNA Binding Mouse Strong Dlx5 transactivates ALP expression, directly by binding to its cognate response element and/or indirectly by stimulating Runx2 expression. The ATTA consensus homeodomain response element in the ALP promoter specifically binds to Dlx5 (EMSA). Jared Roach
Additional Reviewer Comments:
Reviewer: Jared Roach

This is a homeobox gene with a well-established role in development. It has to be a TF.


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Facts about Dlx5 13395RDF feed
Gene description distal-less homeobox 5  +
Gene id 13,395  +
Gene judgment TF Gene  +
Gene symbol dlx5  +, and AI385752  +
Gene taxonomy DNA-Binding: sequence-specific  +
Homolog cluster 103,889  +
Protein family 1.1 Helix-Turn-Helix Group/2 Homeodomain Family  +
Protein group 1.1 Helix-Turn-Helix Group   +
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