Dlx6 13396

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Gene ID: 13396
Gene symbol: dlx6
Gene Description: distal-less homeobox 6
Aliases:
Human Ortholog Gene ID: [1750]
Reviewer Judgement: TF Gene Candidate
Functional Classification: DNA-Binding: sequence-specific
DBD Protein Group Classification: Helix-Turn-Helix Group
DBD Protein Group/Family Classification: Helix-Turn-Helix Group / Homeodomain Family
Homolog Cluster(s): 103889

Evidence:

Pubmed ID Function Species Evidence Strength Reviewer's Comments Reviewer
[9415433] Other Mouse Weak Homeodomain of DLX6 has almost identical sequence with other DLX proteins. The rest of the sequence has high similarity with DLX1/7. EMSA with DLX1 shows that it can bind to NP and WIP oligos, DNA with TAAT core. DLX5 and DLX6 are located in the same bigene cluster. Andrew Kwon
Additional Reviewer Comments:
Reviewer: Andrew Kwon

Based on the fact that DLX6 shares much similarity with other members of the dlx family, and is located in the same bigene cluster as DLX5, for which there is experimental evidence of DNA binding and transcription activation, it's almost certain that DLX6 shares a similar function. There are many literature that reports developmental anomalies with mutant or deleted DLX6. However, as I could not find direct experimental evidence specifically for DLX6, I am classifying this as a candidate only for now.


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Facts about Dlx6 13396RDF feed
Gene description distal-less homeobox 6  +
Gene id 13,396  +
Gene judgment TF Gene Candidate  +
Gene symbol dlx6  +
Gene taxonomy DNA-Binding: sequence-specific  +
Homolog cluster 103,889  +
Protein family 1.1 Helix-Turn-Helix Group/2 Homeodomain Family  +
Protein group 1.1 Helix-Turn-Helix Group   +
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