Dmbx1 140477

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Gene ID: 140477
Gene symbol: dmbx1
Gene Description: diencephalon/mesencephalon homeobox 1
Aliases: Atx; Cdmx; Mbx; Otx3
Human Ortholog Gene ID: [127343]
Reviewer Judgement: TF Gene
Functional Classification: DNA-Binding: sequence-specific
DBD Protein Group Classification: Helix-Turn-Helix Group
DBD Protein Group/Family Classification: Helix-Turn-Helix Group / Homeodomain Family
Homolog Cluster(s): 103889; 104360

Evidence:

Pubmed ID Function Species Evidence Strength Reviewer's Comments Reviewer
[12055180] DNA Binding Mouse Medium Otx3 HD shows strong binding to the HD consensus sequence in EMSA. A partial Otx3 protein (aa 76-148) was expressed as a GST fusion protein in Escherichia coli. Amy Ticoll
Additional Reviewer Comments:
Reviewer: Amy Ticoll

Otx3 HD shows strong binding to the HD consensus sequence in EMSA. Co-transfection of GH3 cells with pP3Ctk-Luc and pCMV-Otx2 stimulated luciferase activity to 29-fold the activity in cells transfected with pP3Ctk-Luc alone.


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Facts about Dmbx1 140477RDF feed
Gene description diencephalon/mesencephalon homeobox 1  +
Gene id 140,477  +
Gene judgment TF Gene  +
Gene symbol dmbx1  +, Atx  +, Cdmx  +, Mbx  +, and Otx3  +
Gene taxonomy DNA-Binding: sequence-specific  +
Homolog cluster 103,889  +, and 104,360  +
Protein family 1.1 Helix-Turn-Helix Group/2 Homeodomain Family  +
Protein group 1.1 Helix-Turn-Helix Group   +
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