Dmtf1 23857

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Gene ID: 23857
Gene symbol: dmtf1
Gene Description: cyclin d binding myb-like transcription factor 1
Aliases: Dimp; Dmp1
Human Ortholog Gene ID: [9988]
Reviewer Judgement: TF Gene
Functional Classification: DNA-Binding: sequence-specific
DBD Protein Group Classification: Helix-Turn-Helix Group
DBD Protein Group/Family Classification: Helix-Turn-Helix Group / Myb Domain Family
Homolog Cluster(s): 17863

Evidence:

Pubmed ID Function Species Evidence Strength Reviewer's Comments Reviewer
[8425553] DNA Binding Mouse Not Selected The Ets family of transcription factors. Gwenael Breard
[9786929] DNA Binding Mouse Strong Regulation of the CD13/aminopeptidase N gene by DMP1, a transcription factor antagonized by D-type cyclins. Gwenael Breard
Additional Reviewer Comments:
Reviewer: Gwenael Breard

DMP1 contains three tandem Myb-like repeats in its central portion that are flanked by acidic transactivating domains at both termini. The Myb-like motifs are required for DNA binding, but unlike other Myb family members, DMP1 binds to nonameric consensus sequences containing core GGA/T residues, a subset of which are also bound by Ets family proteins. This ability of DMP1 to inhibit cell proliferation depends upon its DNA binding and transactivation functions, because mutants disrupted in either of these domains are biologically inert. Inoue et al. demonstrated that DMP1 is responsible of the regulation of CD13 (encoding aminopeptidase N).


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Facts about Dmtf1 23857RDF feed
Gene description cyclin d binding myb-like transcription factor 1  +
Gene id 23,857  +
Gene judgment TF Gene  +
Gene symbol dmtf1  +, Dimp  +, and Dmp1  +
Gene taxonomy DNA-Binding: sequence-specific  +
Homolog cluster 17,863  +
Protein family 1.1 Helix-Turn-Helix Group/100 Myb Domain Family  +
Protein group 1.1 Helix-Turn-Helix Group   +
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