Drap1 66556

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Gene ID: 66556
Gene symbol: drap1
Gene Description: dr1 associated protein 1 (negative cofactor 2 alpha)
Aliases: 2310074H19Rik
Human Ortholog Gene ID: [10589]
Reviewer Judgement: TF Gene
Functional Classification: Transcription Factor Binding: tf co-factor binding
Homolog Cluster(s): 18046

Evidence:

Pubmed ID Function Species Evidence Strength Reviewer's Comments Reviewer
[12471260] TF PPI Mouse Strong Endogenous DRAP1 coimmunoprecipitates with transcription factor FoxH1 transfected in NIH 3T3 cells and GST-FoxH1 in vitro. Binding of a FoxH1-Smad2-Smad4 transcription factor complex (ARF) to the activin-response element from the Xenopus Mix.2 promoter is inhibited by addition of DRAP1 in an electrophoretic mobility shift assay. Experiments conducted with appropriate controls. Amy Ticoll
Additional Reviewer Comments:
Reviewer: Amy Ticoll

Endogenous DRAP1 coimmunoprecipitates with transcription factor FoxH1 transfected in cells and GST-FoxH1 in vitro. In an EMSA, binding of a FoxH1 transcription factor complex (ARF) to the Xenopus Mix.2 promoter is inhibited by addition of DRAP1. Overexpression of DRAP1 inhibits Nodal activity in cotransfection assays (293T cells).


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Facts about Drap1 66556RDF feed
Gene description dr1 associated protein 1 (negative cofactor 2 alpha)  +
Gene id 66,556  +
Gene judgment TF Gene  +
Gene symbol drap1  +, and 2310074H19Rik  +
Gene taxonomy Transcription Factor Binding: tf co-factor binding  +
Homolog cluster 18,046  +
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