E2f1 13555

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Gene ID: 13555
Gene symbol: e2f1
Gene Description: e2f transcription factor 1
Aliases: E2F-1; KIAA4009; mKIAA4009
Human Ortholog Gene ID: [1869]
Reviewer Judgement: TF Gene
Functional Classification: DNA-Binding: sequence-specific
DBD Protein Group Classification: Winged Helix-Turn-Helix
DBD Protein Group/Family Classification: Winged Helix-Turn-Helix / Transcription Factor Family
Homolog Cluster(s): 104394

Evidence:

Pubmed ID Function Species Evidence Strength Reviewer's Comments Reviewer
[16741925] DNA Binding Human Medium ChIP assays in U-87 MG cells indicate E2F-1 associates with the Pur-alpha promoter in vivo. Experiments conducted with appropriate controls. Amy Ticoll
[17178835] DNA Binding Mouse Strong EMSAs using nuclear protein extracted from mouse brain indicate E2F1 binds to a specific region of the NRP-1 promoter. Amy Ticoll
Additional Reviewer Comments:
Reviewer: Amy Ticoll

EMSA and ChIP assays indicate E2F-1 associates with specific promoter regions. Transfection studies indicate E2F1 positively regulates NRP-1.


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Facts about E2f1 13555RDF feed
Gene description e2f transcription factor 1  +
Gene id 13,555  +
Gene judgment TF Gene  +
Gene symbol e2f1  +, E2F-1  +, KIAA4009  +, and mKIAA4009  +
Gene taxonomy DNA-Binding: sequence-specific  +
Homolog cluster 104,394  +
Protein family 1.2 Winged Helix-Turn-Helix/15 Transcription Factor Family  +
Protein group 1.2 Winged Helix-Turn-Helix   +
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